The Top Thing That All Successful Patients Do

Keep Methylation Central

You are about to learn facts that may save or restore your body’s neurological function…
Brain function is critical to maintaining your lifestyle: when your brain function declines, your life deteriorates.
I am Dr. Nancy Mullan, a medial doctor, a complimentary psychiatrist. I help people with chronic illness who are feeling desperate because their bodies and lives are in decline, who want to find the way to recover, and who want to get started on it right now.
The Centrality of Methylation for Neurological Function
Methylation is the process of attaching a one-carbon, three-hydrogen group on to another molecule. It is essential to brain function.
The nerve cells in your body are called neurons. The cell membrane of neurons consist of a double layer of lipids, or fat. In order to be flexible enough to allow nutrition into the cell and waste out of the cell, neuron membranes must be methylated. If your body is not producing enough methyl groups, important structures like neurons don’t get methylated, and do not function optimally.
Your estrogen level is also important for maintaining the integrity of neurons. You lose function in key neural structures when your estrogen levels drop. Either too much or too little estrogen can cause depression, which is related to why women are twice as likely as men to get depressed.
Estrogen is also known to have a protective effect on the motor system involved in Parkinson’s Disease. Low estrogen may lead to tremor, muscle twitches and restless legs, in addition to worse symptoms and disorders.
Estrogen also selectively enhances the main site of memory in your brain. You are familiar with medications used for high cholesterol, the ‘statin drugs’. These drugs interfere with estrogen production by inhibiting the enzyme HMG-CoA-reductase. HMG-CoA-reductase is necessary for cholesterol production in your brain.
Patients taking HMG-CoA-reductase inhibitors get dementia at an earlier age than those not using these medications.

Cholesterol is needed to make not only estrogen, but progesterone and testosterone as well. All of your sex hormones depend on cholesterol for their formation. Sex hormones are essential to neurological and psychiatric function.
Hormones impact your mood and brain because they impact important communication networks in your body. Every biologic function, every brain function, every cell function, is under nervous system control by way of small protein molecules called neurotransmitters (NTs).
NTs are the messenger molecules in your nervous system’s network that coordinate all of the various functions in your body.
NTs function like a key. The receptor for the neurotransmitter (NT) that is embedded in your cell wall is like the lock. When the NT fits into the receptor, it induces your cell to perform the function involved with the particular NT/receptor system.
NT receptor sites are present in every organ and system. There are receptor sites for NTs located in your gastrointestinal tract, on your heart and circulatory system, your endocrine organs, and your immune system. Receptor sites for NTs are everywhere.
Your most important relaxing NT is serotonin. It is your ‘feel good’ NT. It modulates mood and pain pathways. When serotonin drops, it causes depression, anxiety, sleep disturbance, memory loss, impaired concentration and increased pain sensitivity.
Estrogen has receptor sites on every organ and system also. Estrogen supports serotonin. They strengthen one another. So when menopause causes your estrogen levels to drop, your brain function actually declines, and your emotions may become erratic as well.
Estrogen and serotonin work together to enhance thyroid hormone activity. Serotonin impacts thyroid hormone production very directly. There are receptor sites for serotonin in your brain that have a direct effect on how much thyroid stimulating hormone (TSH) your anterior pituitary can produce when it gets a low thyroid hormone signal.
So you can have low thyroid hormone levels, but because you also have low serotonin levels, your body will not display the traditional sign for low thyroid, increased TSH.
In order for you to maintain optimal estrogen levels, your body needs to be making optimal numbers of methyl groups. Below is the central biochemical pathway for making methyl groups:
The Methylation Pathway
Estrogen is deactivated by the COMT enzyme. This enzyme uses methyl groups in that process. You need genetic testing that tells you the status of your COMT enzyme, how fast it works and how many methyl groups it uses.
You need to know the status of all of the genes encoding for the enzymes in your methyl group producing pathways, so you can bypass any problem genetics, and be sure you have the methyl groups you need to perform all of the important functions that involve methyl groups.
My Tuesday night call is your chance to learn what you need to know to get this important area of your biochemistry under control.
I take your questions on many topics, among them the impact of your personal genetics on your biochemistry. I discuss how to balance your biochemistry with nutritional supplements that bypass problem genetics.
It is up to YOU to learn about treating chronic illness successfully, and the role of optimizing both methyl group production and your capacity for methylation.

This is your opportunity.
My Tuesday evening calls are ongoing. They happen every week. There is no charge to come on this call. It is a free forum where you can ask your questions. I am there to help you, and I have a group of experienced patients who will give you their insights also.
It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.
The time: Tuesday at 5:00 PM Pacific Time
(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)
The number to call in the US: (559) 726-1300
The access code: 986935#
International access numbers are available.
Join us to inform yourself so that you can be proactive about your health!
So excellent! I literally learn something on every single call and I get clarification on things that have been lingering in my mind…
You are giving people a huge gift by empowering them… It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
Thank you so much Dr. Mullan. Thank you so, so much for everything you do.
Wow! I have to tell you, this was such an uplifting call. It’s so nice to hear good news especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!


About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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