Methionine – ‘First among Equals’ of Essential Amino Acids

Methionine is a super important amino acid for methylation reactions. It turns into S-adenosyl methionine, SAMe, which is your body’s main methyl donor. Beyond that, it supplies sulfur for detoxification pathways, and acts as a scavenger for pro-oxidant molecules. It needs to be supplied by your diet or supplementation, and your GI tract needs to be in reasonable shape to get it across its mucosal membrane.

In her upcoming book, Dr. Amy Yasko gives this advice about maintaining its levels:

Methionine is a critical part of your cycle for making methyl groups. Low levels of methionine suggest a need to support both the long route, the pathway that uses the MTR/MTRR enzymes, and the short cut, the BHMT pathway.

Amino Assist Spray or capsules can be added for low levels of methionine. For methylation cycle support, use PS/PC/PE, DHA, and All in One. This supports the short cut pathway. Then, MethylMate A can be added. MethylMate A and short cut support can be added even while lithium is still low. Check lithium on a HMT prior to adding extra B12 or higher levels of Black Bear, a source of B12 and molybdenum. Finally, once lithium is in balance, add extra B12 and MethylMate B.

If methionine remains low, you can add sprinkles of methionine. If you are adding methionine, be sure you have support for the methylation cycle in place so you can process the methionine and homocysteine that is generated as a result.

Alternately, high methionine is sometimes seen in those who are ACAT +. The use of ACAT/BHMT capsules may help to restore methionine to healthy, balanced levels. High levels of methionine have also been reported to cause increased tryptophan levels, as well as lower serotonin and GABA. Theoretically, this is due to competition for B vitamins, in particular B6 or P5P. Therefore, if your methionine levels are high, consider Ultimate B, and check tryptophan on a UAA, as well as relative levels of glutamate to GABA.

There is a lot you need to know about getting and /or staying well. My Tuesday night call is your chance to do this. The call is done in a question and answer format. It is not a lecture, although I do jump off of the question and lecture on the topic at hand. Come with your questions. Press *6 to get into the Q and A line.

I discuss how to balance your biochemistry with nutritional supplements that bypass problem genetics.

It is up to YOU to learn about treating chronic illness successfully.

You need to know about the role of optimizing both methyl group production and your capacity for methylation.

This is your opportunity.

My Tuesday evening calls are ongoing. They happen every week. There is no charge to come to the call. It is free forum where you can ask your questions. It’s a great way to clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

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Join us to inform yourself so that you can be proactive about your health!

So excellent! I literally learn something on every single call and I get clarification on things that have been lingering on my mind…

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…

Thank you so much Dr. Mullan. Thank you so, so much for everything you do.

Wow! I have to tell you, this was such an uplifting call. It’s so nice to hear good news especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!


Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA 91505
T: (818) 954-9267 – F: (818) 954-0620


About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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