Histamine — The Good, The Bad, The Ugly…

Many of you are concerned about high histamine. There is a great deal of information out there on it. This is a link to some well organized, comprehensive information: http://www.histamine-intolerance.info/. And if you need more, here is more: http://chriskresser.com/headaches-hives-and-heartburn-could-histamine-be-the-cause.

Below are the comments from Dr. Amy Yasko’s upcoming free, online book about high histadine and histamine:

Low tetrahydrofolate (THF) levels can cause elevated histidine. Elevations in histidine, in turn, cause increased levels of anserine and carnosine. So, high histidine along with high anserine and carnosine may indicate a need for THF.

Consider using All in One or Ultimate B. In addition, check FIGLU levels on a MAP test, as FIGLU will also climb If there is not sufficient THF. Thus, high FIGLU may be an indirect sign of excess histidine.

High levels of histidine may depress the levels of other amino acids, as well as be related to high cholesterol. Tests can be run to look at cholesterol levels. In addition, high histidine can translate to increased histamine which is a factor in allergic reactions and inflammation. This can be exacerbated by low copper, as copper is needed for mono amine oxidase (MAO) activity, which breaks down histamine.

Also, check taurine, as high taurine may indicate increased CBS enzyme activity. Increased CBS activity can generate excess H2S, which may decrease MAO enzyme activity and the breakdown of histamine. This may increase histamine levels. Quercetin can help with high histamine, but quercetin can inhibit COMT, so this can be non optimal for those who are COMT ++. Cherries are a natural source of quercetin, so while cherries may help with inflammation and some forms of arthritis, high quercetin levels may cause problems for those who are COMT ++ who already have slow COMT activity. Licorice can also inhibit MAO, so along with low copper and high H2S, these factors may reduce the breakdown of histamine, allowing higher levels to accumulate. If allergic reactions are an issue, low dose hyperimmune nucleotide blend can be considered.

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Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA 91505
T: (818) 954-9267 – F: (818) 954-0620



About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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