So, what’s the big deal about lithium anyway?

The role of lithium in B12 transport into the cell is critically important.  Peer reviewed work by Tisman, Herbert, and Rosenblatt, published in the British Journal of Haematology, was the first to illustrate that ingestion of lithium is related to B12 binding, B12 binding being necessary for methyl group formation.

Continuing this research, Vanyo and coworkers in Lithium in Biology and Medicine, discuss the finding that lack of lithium and B12 deficiency share physiological features. Supplementation with lithium enhances B12 transport into cells. According to these researchers, lithium is associated with elevated levels of serum B12 binding capacity. Furthermore, this group was able to show that lithium increases the transport of folate into the cell, as well as that of B12.

Additional peer reviewed work by Schrauzer, Biological Trace Element Research, also supports the role of lithium in B12 transport. The addition of lithium was shown by these researchers to lower elevated serum B12 levels, again illustrating lithium’s effecting B12 transport into cells.

Based on this research, it is important to know your lithium levels. When lithium is low and/or serum B12 is particularly high, use lithium supplementation prior to adding more B12. Increasing B12 in the absence of lithium may further deplete lithium levels due to the use of lithium to aid in the transport of the added B12. Ideally, lithium should be in balance prior to adding excess B12 so as not to create lithium depletion.

Lithium plays a range of additional roles in your body aside from B12 and folate transport into your cells, so it is important not to deplete this pivotal trace mineral. Lithium’s impact on mood stabilization has been known and used clinically for many years, despite the fact that the mechanism by which this occurs has not been fully elaborated. Norepinephrine imbalances have been implicated in attention disorders, and researchers have illustrated an impact of lithium on balancing norepinephrine levels.

Researchers have noted and published effects from lithium on neurological conditions. Beta amyloid may play a role in Alzheimers Disease, and lithium has been shown to have neuroprotective effects against beta amyloid.  Research from Spain illustrates that lithium has a positive impact on neural repair after traumatic injury. Other research shows that lithium can enable mitochondrial function.

A need for support for the mitochondrial energy cycle may also be seen with low lithium. Support for mitochondrial energy production can include Mitoforce, ATP, Riboflavin 5 phosphate, NADH, and Krebs minerals.

(Excerpted from Feel Good Biochemistry by Dr. Amy Yasko.

Dr. Mullan would like to invite you to her Open Forum which is held on  Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information. 

The call in number is (605) 562-3140, and the access code is 691392#.

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD

Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620



About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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