The role of lithium in B12 transport into the cell is critically important. Peer reviewed work by Tisman, Herbert, and Rosenblatt, published in the British Journal of Haematology, was the first to illustrate that ingestion of lithium is related to B12 binding, B12 binding being necessary for methyl group formation.
Continuing this research, Vanyo and coworkers in Lithium in Biology and Medicine, discuss the finding that lack of lithium and B12 deficiency share physiological features. Supplementation with lithium enhances B12 transport into cells. According to these researchers, lithium is associated with elevated levels of serum B12 binding capacity. Furthermore, this group was able to show that lithium increases the transport of folate into the cell, as well as that of B12.
Additional peer reviewed work by Schrauzer, Biological Trace Element Research, also supports the role of lithium in B12 transport. The addition of lithium was shown by these researchers to lower elevated serum B12 levels, again illustrating lithium’s effecting B12 transport into cells.
Based on this research, it is important to know your lithium levels. When lithium is low and/or serum B12 is particularly high, use lithium supplementation prior to adding more B12. Increasing B12 in the absence of lithium may further deplete lithium levels due to the use of lithium to aid in the transport of the added B12. Ideally, lithium should be in balance prior to adding excess B12 so as not to create lithium depletion.
Lithium plays a range of additional roles in your body aside from B12 and folate transport into your cells, so it is important not to deplete this pivotal trace mineral. Lithium’s impact on mood stabilization has been known and used clinically for many years, despite the fact that the mechanism by which this occurs has not been fully elaborated. Norepinephrine imbalances have been implicated in attention disorders, and researchers have illustrated an impact of lithium on balancing norepinephrine levels.
Researchers have noted and published effects from lithium on neurological conditions. Beta amyloid may play a role in Alzheimers Disease, and lithium has been shown to have neuroprotective effects against beta amyloid. Research from Spain illustrates that lithium has a positive impact on neural repair after traumatic injury. Other research shows that lithium can enable mitochondrial function.
A need for support for the mitochondrial energy cycle may also be seen with low lithium. Support for mitochondrial energy production can include Mitoforce, ATP, Riboflavin 5 phosphate, NADH, and Krebs minerals.
(Excerpted from Feel Good Biochemistry by Dr. Amy Yasko. http://www.FeelGoodBiochem.com.)
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Nancy Mullan MD
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Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.
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