How much do you know about oxalate?

A number of programs and tests focus on high oxalate, which is also called oxalic acid. Dr. Amy Yasko’s program integrates the issue of high oxalate into a larger concern about overall biochemical balance. The most frequent response to high oxalate is the implementation of a diet low in oxalate foods. This is the quickest way to get oxalate down in the short run. However, there are a number of factors that may trigger high oxalate levels. A determination if the trigger is, for example, high yeast or fungi, a lack of B12, or low ATP, is made through interpretation of testing. The reason for the high oxalate then guides your decisions as to how you address the problem.
High oxalate may be due to yeast and fungal infestation. These factors can be investigated with stool testing and appropriate action taken.
High oxalate can also be caused by low B12. Low B12 makes the Krebs Citric Acid energy cycle run in a reverse direction, which increases oxalate. Check serum B12 or cobalt levels. Keep in mind that many people with chronic health issues turn out to be low lithium. Lithium transports B12 into your cells. If your lithium is low, your B12 and/or folic acid may appear high on serum testing. They are not getting transported into your cells, so high values for these two critical nutrients may indicate that you need to supplement with nutritional lithium.

The Krebs cycle is the energy/ATP  generating function of the mitochondria in your cells. Your level of B12 impacts enzymes in the Krebs cycle, and the levels of Krebs intermediates are affected. Oxalate is a Krebs intermediate. Conditions of B12 deficiency, coming either as a result of mutations in the methylation cycle, and/or by high level depletion of B12 through endurance training or sports, can lead to increased levels of oxalate. High levels of tartrate in the absence of high arabinose, or high levels of fumarate, should lead you to consider supplementing with multiple forms and routes of B12. This includes chewable hydroxyl, adenosyl, and methyl B12. The relative amounts depend on your Nutrigenomics.

If you have high oxalate levels, you should consider increasing your B12 support. Other supplementation also aids in the productive conversion of oxalate.
The levels of certain amino acids may indicate high oxalate. There are three branched chain amino acids, leucine, isoleucine and valine. High leucine in the absence of high valine or isoleucine can occur secondary to low phosphate. This may also cause increases in oxalate, so check to determine if leucine is high and what your phosphate levels are. High oxalate may also be due to excess glycine secondary to SHMT + or excess iron. If threonine is high, this may be an indication of high oxalic acid.

High levels of citrate or high levels of the intermediates that precede acetyl CoA on the Metabolic Analysis Profile diagram, i.e., pyruvate, lactate, etc., may be an indirect indication of high oxalate, as the cycle is not incorporating at 11:00 (oxalate) well enough to be moving around to 1:00 (citrate) properly. Also, a build up at 1:00 (citrate) may be causing a backup in the cycle, which may be an indirect indication of high oxalate.
Aluminum and thallium can impair the function of the Krebs cycle, so address thallium and aluminum if they are found to be elevated.
This information has been excerpted from Dr. Amy’s online book Feel Good Biochemistry, that can be found at

Dr. Mullan would like to invite you to her Open Forum which is held on Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information.

The call in number is (605) 562-3140, and the access code is 691392#.

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD
Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.
2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620


About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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