Where Lithium and Dopamine Come Together

Lithium has been known for years to be useful for mood disorders. No one has described why lithium has this stabilizing impact on mood. And if you have a mutation in the MTHFR C677T gene, you are likely to have mood fluctuations, and you are also likely to have low serum lithium levels.

Lithium comes together with MTHFR, methylation and dopamine at the enzyme catechol-o-methyl-transferase, or COMT. COMT deactivates the neurotransmitter dopamine. It uses methyl groups to do this, and MTHFR is important in the production of methyl groups.

Lithium increases the transport of B12 and folate into the cell. B12 and folate are pivotal substances in the production of methyl groups, which happens inside cells. So lithium supports the production of methyl groups inside the cell.

Lithium may also increase the production of COMT, which then uses the methyl groups MTHFR helps to make to deactivate dopamine. So, one of the modes of action of lithium may be to reduce the level of dopamine in the body by enhancing the production of methyl groups and increasing the level of COMT.

Dr. Amy Yasko noted that a number of adults and children using her protocol have low lithium levels. She started looking carefully at lithium levels and noticed correlations between low lithium, symptom formation and particular mutations in the methyl group producing pathway. Certain SNPs are associated with excess lithium excretion, in particular MTR+.

Lithium is an essential trace element. You must get it from your diet. The average intake of lithium from the diet should be up to 3100 mcg, or 3.1 mg, per day. It may take significantly more to increase your serum lithium levels into the normal range. If you check your serum lithium levels, you may be astonished to find that they are very low, even below detectable levels. This is not because you are not taking pharmaceutical lithium. The serum lithium test is not just to measure pharmaceutical lithium. It measures the trace amounts of lithium in your body also.

So now it is up to YOU to learn more about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy

This is your opportunity.

My Tuesday evening calls are ongoing. They happen every week. There is no charge to come to the call. It is free forum where you can ask your questions. It’s a great way to clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time: Tuesday at 5:00 PM Pacific Time

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Join us to inform yourself so that you can be proactive about your health!

So excellent! I literally learn something on every single call and I get clarification on things that have been lingering on my mind…

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…

Thank you so much Dr. Mullan. Thank you so, so much for everything you do.

Wow! I have to tell you, this was such an uplifting call. It’s so nice to hear good news especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!

This is brilliant. I hope a lot of people not doing methylation work will see this. I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…


Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA 91505
T: (818) 954-9267 – F: (818) 954-0620



About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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