New Years Resolution: I will make these emails short, understandable, and relevant clinically…

Starting out, if you have mutations in your methyl group producing pathways, it is important to get your methylation cycle moving again to produce methyl groups. This enhances your immunity and provides regulation of your genetic material. It enables the myriad reactions that methyl groups perform in your body. It is faster and provokes fewer unwanted reactions to induce activity in your BHMT pathway first. This is the pathway that goes directly from homocysteine to methionine in the image below.


If this is confusing to you, go to the home page of my web site,, and download the e book you find there. Chapter three describes the basics of what I am talking about. It takes some repetition to finally grasp and use these concepts.

Over time, when you are able to support MTR, MTRR and MTHFR C677T mutations so that the long way around the cycle can function properly, then your body will not need to rely as heavily on the shortcut through the BHMT enzyme.

There are advantages to supporting so that you are able to go around the cycle, that is to use the “long route”, as well as the “short cut”. As a result, it is important to supplement with low doses of a range of supplements that support all of the weak points of the methylation cycle. So Dr. Amy developed All in One, her basic multivitamin. It is the first vitamin you try, unless you know you cannot tolerate multivitamins, or there is something in it that you definitely should not be taking. You start out with a tiny amount of it, something like the amount you can fit on the broad end of a toothpick. You stay at that amount until you have clarity about what increasing the amount will be like. You do not have to get up to any particular dose. Most people have no trouble with it and can easily get up to 3 caps per day.
The next thing to add is DHA, the fish oil, docosahexaenoic acid. You are not using massive doses of this, 200-300 IU per day. Do not take a lot of EPA, eicosapentaenoic acid, the fish oil usually found with DHA. Do not take more EPA than DHA. Most people tolerate DHA really well. If you know that you are sensitive to supplements, start with a tiny amount, like one drop, and work up. DHA pushes the shortcut route, the BHMT pathway.
Next you would try to add some Phosphatidylserine Complex, or PS/PC/PE, as Dr. Amy has formulated it. This also pushes the shortcut pathway. Use Dr. Amy’s formulation, the one found at It is SKU# 01043. It is a soft gel cap. Pierce the cap and start with a tiny amount if you are sensitive to supplements. Start slow, see what happens.

This is a foundation for methyl group production. It is just the beginning. You will be introducing other supplements as testing and your clinical condition indicate. Your gastrointestinal tract usually needs to be addressed, and you may have issues with mitochondrial function and/or fatty acid metabolism. My plan is to continue walking you through each of these areas, telling you how I work and how I think to undo some of your confusion. It is not simple, it is not kitchen medicine. You do need guidance. My Tuesday night Open Forum is there to help you.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity.

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
International access numbers are linked here.
Join us to inform yourself so that you can be proactive about your health!

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…


Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA  91505
Phone/Fax: (818) 954-9267


About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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