Lithium — the next step

This is the third article in a series called Treating Chronic Illness that started at the beginning of January 2016. For background information about methylation and MTHFR, download The Methyl Group: What It Can Do for You found on the home page of For previous articles in this series, and all previous informational posts by Dr. Mullan, look at

So now, things going as hoped, you have started broad support of methylation by using Dr. Amy Yasko’s All in One multivitamin, and the shortcut support afforded by DHA and Phosphatidyl Serine. You do not want massive doses of DHA, 200 – 300 IU being all that is usually necessary for this purpose. Lipids slow down the Nitric Oxide Synthase (NOS) enzyme that works in the kidney to help excrete toxins, so hold lipids to moderate levels. This includes liposomal supplements also.

The Phosphatidyl Serine you use should be formulated similarly to Dr. Amy’s product found at (SKU# 01043). There are a lot of Phosphatidyl Serines out there.  They all have very different formulations. Nature’s Way has a product that is similar to Dr. Amy’s.

At this point, you want to start thinking about lithium. Lithium is important for a number of reasons. They are detailed in older posts that you will find on the blog mentioned above. The big deal for our purpose is that lithium enhances the uptake of B12 into the cell. You need B12 in your cell to make methyl groups. Methyl group formation happens in the cells of the liver, kidneys and brain.

If you get a serum B12 and it is high, don’t freak out. It most likely means your lithium levels are low. B12 is completely non-toxic, so don’t worry about it. Don’t go on a rampage to lower your B12. Get a serum lithium level, or use hair and urine testing to determine what it is.  Standard serum lithium blood tests show the correct ranges even for people who are not taking pharmaceutical lithium. You may be low.  You may be below detectable range. Many people with chronic illness are low in lithium, and people with MTR + will dump it.

When you start taking lithium, you may see a reaction, especially if you are sensitive to supplementation. By supplement reaction, I mean any symptom that starts as soon as you start taking a particular supplement or shortly thereafter. You know and recognize it because you have started supplements one at a time and have learned how to figure out when something you started taking is having an impact.

Start with a very low dose of lithium so that if you do have a reaction, it is not a big one. It will pass. Keep the amount of any supplement that gives you a reaction low. Be sure that you know the difference between a reaction from a supplement that is beneficial versus a reaction that means that you should not be taking that particular supplement. More on this next week…

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity. 

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

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Join us to inform yourself so that you can be proactive about your health!


So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…


Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818) 954-9267


About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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