This information is pivotal…

This is the next article in a series that started at the beginning of January 2016. For background information about methylation and MTHFR, download The Methyl Group: What It Can Do for You found on the home page For previous articles in this series, and all previous informational posts by Dr. Mullan, look at

When you take a supplement and have a reaction, how do you know why it is happening and what you should do? This issue has to be examined in the light of what you know about your body and what you know about the function of the supplement you are adding.

Some supplements have no toxicity in routine doses and are absolutely essential to methyl group formation. These are the ones that are important to include in your program, even though you may have to do this over time. If you are reacting to these, you definitely need to research out why.

If you cannot take anything without reacting, and you have tried many supplements at different times, check your environment for mold and your water for heavy metal toxins, imbalanced minerals or other impurities. You will not succeed if you cannot tolerate nutritional supplements. Do not guess about this. You need to test.

If you know that you routinely react to anything you take, then you certainly know to expect a reaction when you try anything new. Start with very, very tiny amounts. If it is a liquid sublingual, dilute it way down and start with a tiny amount of the dilution. Whatever it is, start with an amount that is so small that if you do react to it, you can tolerate the reaction.  You can work up over time if necessary. Sometimes tiny amounts are sufficient. Keep the doses of whatever you are trying low, at least initially, so your body has the chance to get used to the change in chemistry.

Make sure that what you are trying is essential, absolutely necessary for you to get into your program, and has no inherent toxicity. Vitamin B12 is an example of this kind of supplement.  It is not the first thing to put in to your program, neither is 5-methyltetrahydrofolate, even though you may need both. You need a foundation of minerals, amino acids, and other substances before you add B12, 5-methyltetrahydrofolate, or other nutrients essential to methyl group formation. Even if you are not routinely reactive to supplements, you will react if you attempt to stimulate methyl group formation without a good foundation.

Sometimes you know that a supplement has something in it that you will not tolerate in even tiny amounts, like curcumin, dairy, or salicylates. If you know this for sure, do not try to wade in on that supplement.  Use something else. However, a supplement is not a serving of food. It is a tiny amount compared to that. You may tolerate something in a supplement that you do not tolerate in food.

If your amino acids are all low, you will be predisposed to react to supplements. Methylation reactions are catalyzed by enzymes. Enzymes are made from amino acids. Nothing works well with low amino acids. Your amino acids may be low because of too little protein in your diet, or insufficient digestion and absorption of the protein you are eating. Then your attention needs to turn to your gastrointestinal tract.

If your reactivity to a supplement persists in spite of low dosing over time and what you think is a good foundation, stop the supplement and turn to testing to find some answers.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity. 

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

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International access numbers are linked here.

Join us to inform yourself so that you can be proactive about your health!


So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…


You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…


Nancy Mullan MDAuthor, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818)

About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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