What To Do About Reactions To Supplements…

The following is from a patient of mine who is learning how to use this protocol to solve a chronic GI issue. I gave him my customary direction: if you react to a particular supplement, reduce the amount until you have very little reaction and hold it there until you can increase by very tiny increments. Tiny is just that. Tiny….

He came back with the following:

I am an engineer and have been trained in critical thinking and failure analysis. If I would characterize your approach to supplementation it would be reduce the amount to decrease reaction until you can tolerate it. I would call this a zero point slope phenomena and it works well in most cases. I also on the whole support that strategy. However there are some processes in nature that act differently.

For example, the way that gas in your car or rocket fuel works. Both require an initiation spark in order to start the process, but once started, the process is self-sustaining until complete. It is nearly impossible to control the reaction by input alone, but the question is, can the reaction be controlled by another substance to get the desired result? That is what is done in car and rocket engines.

What this means for you and your body is this: you may get a reaction when you start a certain supplement. The reaction may be uncomfortable, but the supplement may actually be moving things in a positive direction. If you just knee jerk reaction stop the supplement, you may be removing something that you need.

Can you reduce the supplement down to where it gives you a reaction that you can stand? That is the zero point slope referred to above. Mostly this works, but what about when it does not? Well, you may be able to take something in addition that controls your reaction. You can both take a tiny amount of the substance to which you are reacting and use another supplement, or a pharmaceutical, to control your reaction.

Lithium, for example. If you know your lithium is low, the standard blood test ranges for serum lithium being correct whether you are taking pharmaceutical lithium or not, then you need to get lithium into your body. Dr. Amy Yasko has a liquid lithium that is only 50 mcg per drop. You can even dilute the drops, but you may die of old age before you get any lithium on board.

You can attempt to control the reaction by using lithium that has been combined into another product, like All in One or BeCalm. Sometimes that works. You can also go on to lay in more nutritional foundation and go back to lithium to see if you can tolerate it later in your program. Sometimes that works. What does not work is to bypass lithium or any other nutrient essential to enhancing methylation.

Beyond all this, you need to get to know your body so that you have some idea of what is happening when you add a nutrient that you need, but you are just not tolerating it. You need to do some testing to get answers. And you need to be a detective and look for clues about what is going on.

If you are reacting to everything you try to take, then look in your environment for the problem. Look for mold in your house or problems with your water. These are the most common problems that Dr. Amy and I have uncovered, but there can be others, like lead in the paint in your house that leaves a fine, lead laden dust every time you open a window. There may be a toxin contaminating your living space. There can be electric pollution like EMFs… Look for these problems now because it is possible for you to get more and more ill, and for your resources to get more and more taxed and diminished.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity.

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call. It is a free forum where you can ask your questions. It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

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Join us to inform yourself so that you can be proactive about your health!


So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…


You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…


Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818) 954-9267



About Nancy Mullan, MD

Some people call Dr. Nancy Mullan the MTHFR genetic medicine expert. Dr. Mullan works with people who are struggling with chronic disease or other significant illness, who are willing to use diet and genetics-based nutritional supplementation, and who want to increase wellbeing and energy, enhance immunity, lift mood, fine-tune genetic function, and get their lives back. Dr. Mullan has studied at a number of exceptional institutions: the University of Pennsylvania, Tufts University School of Medicine, and the University of Chicago Hospitals and Clinics. She excels at integrating the results of biochemical and genetic testing into sustained clinical improvement for you. She has succeeded with patients who confounded the specialists at Massachusetts General Hospital, the Mayo Clinic, the Cleveland Clinic, Stanford, and many well-known integrative medical doctors. When recommending her, her patients say, “This is the woman you need to talk to. She really knows how to handle tough clinical problems.” Dr. Mullan's specialty areas are MTHFR+, methylation genetics, and genetics-based nutritional supplementation. Within this context, she most often works with Chronic Fatigue Syndrome, Lyme Disease, Psychiatric Disorders, Autism Spectrum Disorders, Women’s Health Issues, Thyroid Disorder, Gastrointestinal Disorder, and Heavy Metal Toxicity.
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