Folate — What’s in it for You

Folic acid deficiency results in the inability to degrade formiminoglutamic acid (FIGLU). As a result, FIGLU accumulates in your urine. High FIGLU on an organic acid test is a marker for low folate.

It is important to use both folic acid and folate supplementation for several reasons. The pathway that involves MTHFS, an enzyme in the methylation pathway, functions in the folate cycle. There it catalyzes a reaction that turns formyl tetrahydrofolate, or folinic acid, into tetrahydrofolate (THF). THF is what you ordinarily think of as folic acid.


MTHFS also impacts the formation of two purines that are necessary for DNA and RNA formation. DNA and RNA are important for the formation of fast turnover cells like blood cells, GI tract lining, or wound healing. If you have a mutation that reduces MTHFS activity, folinic acid can build up to high levels. When that happens, your synthesis of these purines is reduced, and your tetrahydrofolate level is also decreased.

I work with Dr. Amy Yasko. Her program uses only low dose folinic acid so that this build up does not occur. The two purines are supplemented to support DNA and RNA production, and low dose folic acid along with probiotics are added as a secondary way to make THF. In this way, the impact of any possible MTHFS mutation is bypassed, even if you not have data regarding this gene.

Dr. Amy covers all her bases when adding nutritional support. She includes low dose 5 methyl THF in her supplementation because that is the only way to bypass an MTHFR C677T mutation. No amount of folinic acid, folate, or folic acid will do it. Using high dose 5 methyl THF at the beginning of a treatment for MTHFR + can trigger more detox than is optimal, especially for an adult. Your body may need nutritional groundwork to ease into 5 methyl THF administration.

Folate is basically a chain of glutamates. The difference between folic acid and folate is the stability of the  molecule and the length of their glutamate chains. So, if you are MTHFR C677T++ and you take high dose folate, you potentially have a chain of unused glutamate molecules left in your body. You cannot process it efficiently to 5 methyl THF because of your mutation. There is the risk of folate’s breaking down to release glutamate. Most of the folate that is used for Dr. Amy’s program is 5 methyl THF, with some low dose folinic acid.

Dr. Amy has specific reasons for the choices she makes in terms of supplements and the forms that she uses. The RDA for folate/folic acid is 300 micrograms for a child that is 1 year old, and up to 1,000 micrograms daily for an individual 19 years of age or older. Thus, the 15 to 40 micrograms used for her program is not an issue, especially since the body does need some folate and folic acid aside from the need for 5 methyl THF and folinic. To put this in an easily understandable perspective, a bowl of cheerios has 400 micrograms of folic acid, as compared to the 15 to 40 micrograms used in her program.

If you are MTHFR C677T or have other methylation genetic issues, you may not be satisfied with the treatments you have tried. You may still be tired, hurting, brain fogged, depressed, or having gut or auto immune issues. You need a medical professional who know this area and who can help. Contact Dr. Mullan at NancyMullanMD@aol.com for information or to set up an office visit or remote appointment.

Posted in Epigenetics, MTHFR+ | Tagged

Of Mice and Men…Inheriting epigenetic changes.

The intracellular environment surrounding your DNA can either help repair problems in your DNA structure, or make those problems worse. This happens because of ‘epigenetic’ changes, changes in the expression of the gene because of what is ‘epi’ or around the gene.

It is only common sense that different substances in the environment surrounding the gene itself would make the gene function differently. This is where heredity and environment interface.

Methyl groups are one of the most important substances that can impact genes this way. Methyl groups are primary epigenetic modifiers of DNA. Methyl groups are made of one carbon and three hydrogen molecules. They attach to and regulate the function of the DNA.

These epigenetic changes are inheritable. The two mice above are genetically identical. Their mothers were fed differently, hence their differences. The obese white mouse on the left had a mother who was fed regular mouse rations.

The smaller brown mouse on the right is normal. His mother was fed a diet with added B12, folic acid and methyl donors. B12 and folic acid enhance methyl group formation.

None of this is news to you. What is news is that researchers have uncovered that a human mother’s diet before conception can permanently affect how her child’s genes function. According to a study published in Nature Communications, this is the first evidence of the effect in humans.

The study utilized a unique ‘experiment of nature’ in rural Gambia, where the population’s dependence on grown foods and a markedly seasonal climate impose a large difference in people’s dietary patterns
between rainy and dry seasons.

While a child’s genes are inherited directly from their parents, how these genes are expressed is controlled through ‘epigenetic’ modifications to the DNA. One such modification involves tagging gene regions with methyl groups that results in silencing the genes.  The addition of methyl groups requires key nutrients including folate, vitamins B2, B6 and B12, choline and methionine.

Senior author Dr. Branwen Hennig, Senior Investigator Scientist at the MRC Gambia Unit and the London School of Hygiene & Tropical Medicine, said:

“Our results represent the first demonstration in humans that a mother’s nutritional well-being at the time of conception can change how her child’s genes will be interpreted, with a life-long impact.”

The researchers found that infants from rainy season conceptions had consistently higher rates of methyl groups present in all six genes they studied, and that these were linked to nutrient levels in the mother’s blood.

Strong associations were found with two compounds in particular, homocysteine and cysteine, and the mothers’ body mass index (BMI) had an additional influence.

Andrew Prentice, Professor of International Nutrition at the London School of Hygiene & Tropical Medicine, said:

“Our on-going research is yielding strong indications that the methylation machinery can be disrupted by nutrient deficiencies and that this can lead to disease. Our ultimate goal is to define an optimal diet for mothers-to-be that would prevent defects in the methylation process. Pre-conceptional folic acid is already used to prevent defects in embryos. Now our research is pointing towards the need for a cocktail of nutrients, which could come from the diet or from supplements.”

There is an e book on www.NancyMullanMD.com called The Methyl Group: What It Can Do for You, Plus Three Mistakes Not to Make with MTHFR. It goes into these issues more and includes a description of which genes specifically impact methyl group production. This is important information if your body is not functioning properly.

Posted in Uncategorized

I’d rather try to change someone’s religion than his diet. Sidney Baker, MD

Every time I tell the average person that it is necessary to eat organic, I cringe a little. I know that it automatically puts me in the same category as a wacked out nut. They think about all the restaurants that are immediately wiped off of their lists, and about how expensive organic food is. I loose credibility with that one thing.

Pretty much everyone in the functional health community knows about he dangers of glyphosate, the active ingredient in Round Up, Monsanto’s infamous weed killer. Its use on crops has increased dramatically over the last 15 to 20 years. Corn, soy, wheat, canola, sugar beets and alfalfa are grown in huge amounts in the US and Canada. These crops have been genetically engineered to resist being killed by glyphosate, and they are sprayed with copious amounts of it. So, North Americans are getting more exposure to it in our food than ever before. The US uses 25% of the world’s supply of Round Up. We eat more glyphosate than any other nation in the world, and we don’t really know that it’s safe.

Monsanto claims that they provided safety studies 30 years ago, but independent investigators looking at the studies claim that the data are not proof of safety. Particularly around the issue of cancer, specifically mammary (breast) cancer, the studies seem to have been manipulated to make the chemical appear safe, when in fact, it is not. The increased use of glyphosate correlates with the increased incidence of diseases like diabetes, autism, ADHD, Alzheimer’s, Celiac Disease, Irritable Bowel Syndrome, kidney disease/cancer and liver disease. The curves match remarkably well, according to Massachusetts Institute of Technology Computer Sciences professor Stephanie Seneff. (people.csail.mit.edu/seneff)

Glyphosate interferes with your body’s function in the following ways:

Energy production in the mitochondria is disturbed.
The function of important minerals such as sulfur and manganese is being compromised.
Gastrointestinal bacteria are being killed and replaced with non-optimal organisms.
Bile acid metabolism is negatively impacted.
Folic acid metabolism is disturbed.
Estrogen metabolism is disrupted.

Glyphosate was introduced in 1975. GMO Round Up ready crops were introduced in 1996. Since 1996, an explosion of Round Up that increases every year has been sprayed on food crops. Predictably, weeds have become resistant to this toxin, so now Monsanto has added another chemical to Round Up, a component of agent orange, that makes Round Up 1000 times more toxic.

You need to eat organic food. I am sorry to tell you this, but if you want to remain healthy and free of degenerative disease, you need to eat organic.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity.

Check out my YouTube video

Fine Tuning Your Treatment of Chronic Illness with MTHFR Genetics

What people are saying about Dr. Mullan’s work:

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

Nancy Mullan MD
Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness,
including MTHFR+, Lyme and Autism Spectrum Disorders.

Posted in Chronic Disease, Epigenetics, Excitotoxicity, Monsanto GMO Chemicals, MTHFR+, Treating Chronic Illness Series | Tagged , , , ,

Lithium’s Pivotal Role in Your Body

Lithium has been known for years to be useful for bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact. It is likely to be an effect on multiple pathways, since there are a number of enzymes in the body that are activated or inhibited by lithium.

Lithium comes together with methylation at COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down dopamine and nor epinephrine. Dopamine is a critical neurotransmitter for motivation, focus and attention, among other functions. Nor epinephrine is involved with modulating the impact of stressors. Both are central to nervous system function.

COMT uses methyl groups to accomplish this deactivation. COMT –/– breaks down dopamine at a steady even rate and uses significant numbers of methyl groups. COMT +/+ breaks down these neurotransmitters more slowly and uses fewer methyl groups.

We know that giving a patient more methyl groups than they can use produces symptoms. They get mood swings and start to look bipolar. Children will become hyperactive, ‘stimmy’ or get other symptoms when they are put on methyl B12 if it is too much for them.

Lithium may inhibit the production of a central enzyme in the sulfur system, thioredoxin reductase. It appears that lithium may be increasing the production of COMT and inhibiting the production of thioredoxin reductase. COMT and thioredoxin reductase have genes that are on opposite strands of chromosome 22. Their promoter regions overlap which implies some mutual regulation. Having a shared promoter means that at any given time you can make either COMT or you can make thioredoxin, but you cannot make both.

This circumstance is analogous to a roadway being closed down to one lane. The line of traffic can move only in one direction at a time. One lane is stopped while the other one can go. A shared promoter generates the same situation in gene transcription. You can make either COMT or thioredoxin, but not both at the same time.

Dr. Amy emphasizes that this is her hypothesis, it is not scientific fact. But based on this hypothesis, she started looking carefully at lithium levels and opened up a whole new area in her program. Using this hypothesis makes a difference for patients. She noticed that MTR+ is associated with excess lithium excretion. An out of balance methylation cycle will also cause increased lithium excretion. The vast, vast majority of patients using this protocol come in with low lithium levels.

Dr. Amy suggests only low dose lithium support because lithium also inhibits ribonucleotide reductase. Ribonucleotide reductase takes ribonucleotides, ie, RNAs, and breaks them down into building blocks for DNA and other RNAs. So one of the toxic impacts of high dose lithium is this impact on RNA breakdown. You need to support with DNA building blocks, for example using Nucleotide Immune Support. The RNA formulas also supply these building blocks.

Lithium is an essential trace element. You must get it from your diet. The average intake of lithium from the diet should be up to 3100 mcg, or 3.1 mg. Dr. Amy wants to supplement with very low level lithium, around 2.5 mg. She wants to do it consistently and she does not want to get near biologic doses. What it takes to actually increase a patient’s lithium levels can be significantly more, especially with sicker patients.

You have to keep watching the lithium and cobalt levels on a UEE. High lithium levels on a UEE may indicate excess excretion, but when cobalt, the oxidized form of B12, starts to show, you know the lithium level is coming into balance and you can start to push the long route instead of just the short route.

Why is this important?

There is a connection between lithium and COMT, bipolar disorder and schizophrenia (SZ). It is possible that imbalances in the COMT pathway need regulation by low dose lithium in order to get the kind of levels of COMT that you need for proper dopamine processing. When the levels of COMT in the brains of patients with SZ and bipolar disorder were compared with normal controls, the levels of COMT in those affected were lower than in controls. Lithium seems to increase the activity of COMT.

Lithium induces B12 transport into the cells thus driving the long route. This can happen with just the standing levels of B12 without additional supplementation. B12 binding capacity as well as white count will go up in the presence of lithium. B12 deficiency is known to lead to degeneration of the central nervous system and psychiatric disturbances such as affective disorders and manic psychosis. Violent criminals as a group have the lowest levels of lithium in hair. There is not only a relationship between lithium, B12 and folate, but also between low lithium and anxiety, aggression, bipolar disorder and SZ.

In studies with patients known to be low in B12, the following psychiatric manifestations were reported to remit with vitamin B12 therapy: confusion , hallucinations, delusions, disorientation, confabulation, anxiety, restlessness, fatigue, depression, irritability, sleepiness, psychosis, stupor, slowed ability to process thoughts, decreased memory, acute delirium, mania, apathy, lack of energy, weakness, violent behavior, flight of ideas, negativism and acute paranoid states. These symptoms may occur in the absence of hematological evidence of B12 deficiency.

So certain behavioral problems, depression and learning disability could be caused or aggravated by low nutritional intake of lithium coupled with marginal deficiencies of B12.

Lithium has a direct effect on nor epinephrine pathways. Lithium indirectly inhibits thioredoxin reductase. There is an inverse relationship between thioredoxin reductase and COMT, so it may be that lithium increases COMT leading to decreased nor-epinephrine.

Other positives of lithium:

Lithium stimulates tyrosine hydroxylase, which is a secondary pathway to dopamine production.

Lithium has neuroprotective actions against a variety of insults. It increases GABA activity. It helps to protect against glutamate excitotoxicity by inhibiting the NMDA receptor induced calcium influx.

Lithium plays a role with sodium and potassium balance.

Lithium may help to repair neurons and reduce some of the trauma after injury.

It induces enhancement of mitochondrial oxidative phosphorylation in human brain tissue.

It plays a role with respect to myelination by enhancing the expression of brain derived neurotrophic factor.

And finally, lithium has been shown to be protective in Alzheimer’s disease.

Fine Tuning Your Treatment of Chronic Illness

https://www.youtube.com/channel/UCdJ9BQt2H6Y01Jx_6zMcZVA

What people like you are saying about Dr. Mullan’s work:

So excellent! I literally learn something every single time and I get clarification on things that have been lingering in my mind…
VB

You are giving people a huge gift by empowering them… It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan. Thank you so, so much for everything you do.
MS

Wow! I have to tell you, this was such an uplifting session. It’s so nice to hear good news especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

Nancy Mullan MD
Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness,
including MTHFR+, Lyme and Autism Spectrum Disorders.

2829 Burbank Blvd., Suite 202, Burbank, CA 91505
Telephone/Fax: (818) 954-9267

NancyMullanMD@aol.com
www.NancyMullanMD.com

Copyright © 2016 Nancy Mullan MD, All rights reserved.
You are receiving this email because you opted in at my website or inquired about my practice.Our mailing address is:

Nancy Mullan MD

2829 Burbank Blvd.
Suite 202

Burbank, CA 91505

Posted in Chronic Disease, Dopamine and Dopamine Signaling, Epigenetics, MTHFR+, Treating Chronic Illness Series, Uncategorized | Tagged , , , , , , ,

Critical Keys to Getting Over Psychiatric Symptoms

Keep Methylation Central

There are few things that destroy your life as immediately and completely as the cognitive function loss involved with neuropsychiatric syndromes.

I am Dr. Nancy Mullan. I help people who have mental function disability because of psychosis or a mood disorder, who want to feel their heads and lives quit swirling, and make progress toward their most important goals.

This discussion concerns the neurotransmitter dopamine. Dopamine is responsible for attention, motivation, and reward motivated behavior. It is an important neurotransmitter. It is the predominant neurotransmitter in your pre-frontal cortex (PFC).


Cognitive behavior is processed in your PFC. It is where your executive function resides. It’s the brain power you use to cross the street,  the mental apparatus that you need to make decisions. It’s the seat of your personality, the home of all the characteristics that make you you.

The levels of dopamine in your PFC determine how well it functions. All of the genes and the biochemical pathways that impact these levels are tremendously important to your cognitive function.

One of these genes is the catechol O-methyltransferase (COMT) gene. The COMT gene is named after the enzyme. The COMT gene encodes the production of the COMT enzyme.

Catechol-O-methyltransferase, the enzyme, deactivates dopamine. So both the gene and the enzyme are very involved with the level of dopamine in the brain, and both are important to cognitive processing.

A SNP in the COMT gene decreases the activity of the COMT enzyme, so less dopamine gets deactivated. As a result, the dopamine levels in the brain may become higher than optimal.

Methyl groups are needed to deactivate dopamine. When the COMT enzyme is less active, fewer methyl groups are used. COMT deactivates less dopamine and uses fewer methyl groups to do so. Your methyl group production and supplementation needs to be less.

Too much methyl group supplementation with a slowed down COMT enzyme can generate depression and mood swings in adults. In children, the symptoms are hyperactivity and stims, among others. Too many methyl groups in your body is a chemical stressor and a tax on your adrenal glands.

Besides having a connection with depression and mood swings, COMT SNPs that slow down enzyme function have been associated with bipolar disorder, schizophrenia, and ADHD. Studies show that COMT enzyme slowdown related to COMT gene SNPs impact executive function, working memory, verbal fluency and intelligence.

Too much dopamine results in intense, psychotic anxiety. Your thinking processes go off, you are ‘not right’. Anti-psychotic medications are all dopamine antagonists. Too much dopamine is very intimately associated with psychosis.

Dopamine is also an important catecholamine, a class of amino acid that includes nor-epinephrine and epinephrine. These are all excitatory neurotransmitters. Too much of any one of these is over stimulating.

It is only common sense that you should know your COMT status so you can adjust your methyl group intake to accommodate it, especially if you are having symptoms or ‘psychological’ problems.

Lithium has been used for psychiatric disorders for more than fifty years. Its mechanism of action is still unknown. Lithium has many functions in the body, and it has a key function in the formation of methyl groups.

B12 and folic acid are essential to methyl group formation, and lithium is critical for the uptake of B12 and folic acid into the cell, which is where the formation of methyl groups happens. Methyl groups are made inside the cells of the liver, kidneys and brain.

Beyond that, lithium may increase the production of the COMT enzyme. So no matter what the status of your COMT gene is, lithium can help to assure that you have enough COMT enzyme to process dopamine and other catecholamines.

There are things you should be doing for psychiatric problems other than taking pharmaceuticals and hoping for the best.

Psych patients have been demonstrated to have the same issues that are seen in other adults with chronic illness.

You may be dealing with immune impairment, gastrointestinal disorders, persistent bacterial and viral infection, yeast infestation, multiple food sensitivities, and heavy metal toxicity. You cannot afford to sit around, take meds and attend day care while your life passes. Your time is too valuable, your life is too precious.

  • Are you ready to discover the role of genetics in your health issue?
  • Have you had it with your mood?
  • Do you believe that you have had all the help there is out there?

I know that you have not.

Read the materials I have put out on optimizing diet, supplementation and methylation capacity. They can be accessed at www.NancyMullanMD.com and https://chronicdiseaserecovery.wordpress.com/ Get familiar with all of the conditions that optimizing these factors can correct.

You need to know the status of all of the genes encoding for the enzymes in your methyl group producing pathways, so you can bypass any problem genetics, and be sure you have the methyl groups you need to perform all of the important functions that involve methyl groups, including keeping your dopamine at optimal levels.

It is up to YOU to learn about treating psychiatric illness successfully, and the role of optimizing both methyl group production and your capacity for methylation.

Check out my new YouTube video

Fine Tuning Your Treatment of Chronic Illness with MTHFR Genetics

What people are saying about Dr.Mullan’s work:

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

All the best,
Dr. Mullan’s Office

Posted in Autism, Chronic Disease, Dopamine and Dopamine Signaling, Epigenetics, Excitotoxicity, MTHFR+, Treating Chronic Illness Series | Tagged , , , , , ,

Why Your Brain Works Better When You Methylate

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This article concerns attention, attention based learning, and D4 dopamine receptors.

The membrane surrounding your cell, the plasma or cell membrane, is represented here by a three dimensional fluid mosaic. The cell membrane is composed of a bi-lipid layer, a double layer of lipid or fat, which has a head at one end. The lipid is actually phospholipid.

Nerve cells have a phospholipid cell membrane. In this depiction, the head is represented by the red, green, purple and lime green rounded structures. Anyone who has listened to the Tuesday night calls has heard me talk about phospholipids at length. Phosphatidyl serine complex, that important shortcut support everybody starts out on, is a complex of the same phospholipids that make up the nerve cell wall.

Receptor sites are positioned in the cell membrane. They are represented by pink lobed molecules with antenna-like structures projecting out of them. The antenna-like structures grab the appropriate molecule for the type of receptor involved and transport it into the cell.

The cell membrane must be fluid…. It can’t be rigid. If it is too rigid, the molecules in the membrane can’t move or function properly. They need to be able to move in order to signal appropriately.

Some receptors function by totally inverting into the cell. They invert and pull the substance into the cell by doing so. You cannot have a stiff, inflexible cell membrane and do this effectively. That is what is wrong with trans fats: they are too stiff.

The receptor I am focusing on today is the D4 dopamine receptor. Dopamine is the neurotransmitter responsible for attention, motivation and reward motivated behavior. It is an extraordinarily important neurotransmitter because it is the predominant neurotransmitter in your pre-frontal cortex.

Cognitive behavior is processed in your pre-frontal cortex. It is where your executive function resides. It’s the brain power you use to cross the street, the mental apparatus that you need to make decisions. It’s the seat of your personality, the home of all the characteristics that make you you.

The D4 dopamine receptor is responsible for attention and attention initiated learning. It operates by inverting into the cell. A very fluid cell membrane is necessary to do this.

Methylation of the heads of the phospholipid layers, called phospholipid methylation, or PLM, increases the fluidity of the cell membrane. Dopamine activation of the D4 receptor initiates a cycle of phospholipid methylation.

Depicted above is the bi-lipid layer of the phospholipid cell membrane. The oval structure is a representation of a receptor site which is made of protein.
 
On the left side, there is no phospholipid methylation. There are no methyl groups between the heads of the molecules in the membrane.
 
When there is space made by the methyl groups between the phospholipid heads, there is more room for the receptors to be able to move and function. It is a more fluid membrane. The protein receptor will be able to move around better and will be able to signal and react with other proteins more easily.
 
Inadequate methylation negatively impacts your ability to attend and learn. The dopamine receptor needs to be able to reconfigure itself. It needs to be able to invert itself into the cell and then come back out again. It is not able to do that if the membrane is too solid.
 
Phospholipid methylation, the addition of a methyl group to phospholipids, reduces the packing density of the membrane and enhances the activity of embedded, integral membrane proteins like the D4 receptor.
 
The activity of the D4 receptor mediated phospholipid methylation cycle is affected by the availability of 5 methyl tetrahydrofolate (5 MTHF). When the level of 5 MTHF is decreased, it becomes a limiting factor. The receptors sit waiting for a new methyl group to start the activation. This greatly reduces the impact of any dopamine present. Even very high amounts of dopamine that may be present will not activate the receptor if there is too little 5 MTHF.
 
What determines 5 MTHF availability? The function of the MTHFR C677T mediated enzyme is critical for an adequate supply of 5MTHF. MTHFR 3 is even a more profound down regulation of enzyme activity than MTHFR C677T.
 
Recent work suggests that supporting with methylfolate may be a help in offsetting depression for those who are resistant to SSRI therapy. However, the methylation cycle needs to be supported in a more general way, rather than simply adding methylfolate.
 
Also, we are talking here about appropriate dosing of 5 MTHF for your personal genetics, not the massive amounts of 5 MTHF that is sometimes recommended.
  
You need to know the status of all of the genes encoding for the enzymes in your methyl group producing pathways, so you can bypass any problem genetics, and be sure you have the methyl groups you need to perform all of the important functions that involve methyl groups.

Check out my new YouTube video
Fine Tuning Your Treatment of Chronic Illness with MTHFR Genetics

What people like you are saying about Dr. Mullan’s work:

So excellent! I literally learn something every single time and I get clarification on things that have been lingering in my mind…
VB

 
You are giving people a huge gift by empowering them… It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

 
Thank you so much Dr. Mullan. Thank you so, so much for everything you do.
MS

 
Wow! I have to tell you, this was such an uplifting session. It’s so nice to hear good news especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

Nancy Mullan MD
Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness,
including MTHFR+, Lyme and Autism Spectrum Disorders.

2829 Burbank Blvd., Suite 202, Burbank, CA 91505
Telephone/Fax: (818) 954-9267

NancyMullanMD@aol.com
www.NancyMullanMD.com

Posted in MTHFR+

Fine Tuning Your Treatment of Chronic Illness with MTHFR Genetics

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fine-tuning-your-treatment-of-chronic-illnes

Finally… an organized, simplified explanation
of what Dr. Amy and Dr. Mullan do!

Click on the link below… See what you think!

Fine Tuning Your Treatment of ASD, Psych Disorders and Other Chronic Illness with MTHFR Genetics

What people like you are saying about Dr. Mullan’s work:

So excellent! I literally learn something every single time and I get clarification on things that have been lingering in my mind…
VB

 
You are giving people a huge gift by empowering them… It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

 
Thank you so much Dr. Mullan. Thank you so, so much for everything you do.
MS

 
Wow! I have to tell you, this was such an uplifting session. It’s so nice to hear good news especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

Nancy Mullan MD
Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness,
including MTHFR+, Lyme and Autism Spectrum Disorders.

2829 Burbank Blvd., Suite 202, Burbank, CA 91505
Telephone/Fax: (818) 954-9267

NancyMullanMD@aol.com
www.NancyMullanMD.com

Posted in Uncategorized