I’d rather try to change someone’s religion than his diet… Sidney Baker, MD

This is the next article in a series that started in January 2016. For background information about methylation and MTHFR, download The Methyl Group: What It Can Do for You found on the home page of http://www.NancyMullanMD.com. For previous articles in this series, and all previous informational posts by Dr. Mullan, look at http://www.nancymullanmd.com/blog.

Every time I try to tell the average person that it is necessary to eat organic, I cringe a little. I know that it automatically puts me in the same category as a wacked out nut. They think about all the restaurants that are immediately wiped off of their lists, and about how expensive organic food is. I loose credibility with that one thing.

Pretty much everyone in the functional health community knows about the dangers of glyphosate, the active ingredient in Round Up, Monsanto’s infamous weed killer. Its use on crops has increased dramatically over the last 15 to 20 years. Corn, soy, wheat, canola, sugar beets and alfalfa are grown in huge amounts in the US and Canada. These crops have been genetically engineered to resist being killed by glyphosate, and they are sprayed with copious amounts of it. So, North Americans are getting more exposure to it in our food than ever before. The US uses 25% of the world’s supply of Round Up. We eat more glyphosate than any other nation in the world, and we don’t really know that it’s safe.

Monsanto claims that they provided safety studies 30 years ago, but independent investigators looking at the studies claim that the data are not proof of safety. Particularly around the issue of cancer, specifically mammary (breast) cancer, the studies seem to have been manipulated to make the chemical appear safe, when in fact, it is not. The increased use of glyphosate correlates with the increased incidence of diseases like diabetes, autism, ADHD, Alzheimer’s, Celiac Disease, Irritable Bowel Syndrome, kidney disease/cancer and liver disease. The curves match remarkably well, according to Massachusetts Institute of Technology Computer Sciences professor Stephanie Seneff. (people.csail.mit.edu/seneff)

Glyphosate interferes with your body’s function in the following ways:

  • Energy production in the mitochondria is disturbed.
  • The function of important minerals such as sulfur and manganese is being compromised.
  • Gastrointestinal bacteria are being killed and replaced with non-optimal organisms.
  • Bile acid metabolism is negatively impacted.
  • Folic acid metabolism is disturbed.
  • Estrogen metabolism is disrupted.

Glyphosate was introduced in 1975. GMO Round Up ready crops were introduced in 1996. Since 1996, an explosion of Round Up that increases every year has been sprayed on food crops. Predictably, weeds have become resistant to this toxin, so now Monsanto has added another chemical to Round Up, a component of agent orange, that makes Round Up 1000 times more toxic.

You need to eat organic food. I am sorry to tell you this, but if you want to remain healthy and free of degenerative disease, you need to eat organic.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity.

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call. It is a free forum where you can ask your questions. It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time: Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#

International access numbers are linked here.

Join us to inform yourself so that you can be proactive about your health!
Methylation_Pathway1

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…

VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…
JB

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MDAuthor, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818) 954-9267NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog
Posted in Treating Chronic Illness Series

This information is pivotal…

This is the next article in a series that started at the beginning of January 2016. For background information about methylation and MTHFR, download The Methyl Group: What It Can Do for You found on the home page ofwww.NancyMullanMD.com. For previous articles in this series, and all previous informational posts by Dr. Mullan, look at http://www.nancymullanmd.com/blog.

When you take a supplement and have a reaction, how do you know why it is happening and what you should do? This issue has to be examined in the light of what you know about your body and what you know about the function of the supplement you are adding.

Some supplements have no toxicity in routine doses and are absolutely essential to methyl group formation. These are the ones that are important to include in your program, even though you may have to do this over time. If you are reacting to these, you definitely need to research out why.

If you cannot take anything without reacting, and you have tried many supplements at different times, check your environment for mold and your water for heavy metal toxins, imbalanced minerals or other impurities. You will not succeed if you cannot tolerate nutritional supplements. Do not guess about this. You need to test.

If you know that you routinely react to anything you take, then you certainly know to expect a reaction when you try anything new. Start with very, very tiny amounts. If it is a liquid sublingual, dilute it way down and start with a tiny amount of the dilution. Whatever it is, start with an amount that is so small that if you do react to it, you can tolerate the reaction.  You can work up over time if necessary. Sometimes tiny amounts are sufficient. Keep the doses of whatever you are trying low, at least initially, so your body has the chance to get used to the change in chemistry.

Make sure that what you are trying is essential, absolutely necessary for you to get into your program, and has no inherent toxicity. Vitamin B12 is an example of this kind of supplement.  It is not the first thing to put in to your program, neither is 5-methyltetrahydrofolate, even though you may need both. You need a foundation of minerals, amino acids, and other substances before you add B12, 5-methyltetrahydrofolate, or other nutrients essential to methyl group formation. Even if you are not routinely reactive to supplements, you will react if you attempt to stimulate methyl group formation without a good foundation.

Sometimes you know that a supplement has something in it that you will not tolerate in even tiny amounts, like curcumin, dairy, or salicylates. If you know this for sure, do not try to wade in on that supplement.  Use something else. However, a supplement is not a serving of food. It is a tiny amount compared to that. You may tolerate something in a supplement that you do not tolerate in food.

If your amino acids are all low, you will be predisposed to react to supplements. Methylation reactions are catalyzed by enzymes. Enzymes are made from amino acids. Nothing works well with low amino acids. Your amino acids may be low because of too little protein in your diet, or insufficient digestion and absorption of the protein you are eating. Then your attention needs to turn to your gastrointestinal tract.

If your reactivity to a supplement persists in spite of low dosing over time and what you think is a good foundation, stop the supplement and turn to testing to find some answers.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity. 

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
 
International access numbers are linked here.

Join us to inform yourself so that you can be proactive about your health!

Methylation_Pathway1

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…

VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…
JB

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MDAuthor, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818) 954-9267NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog
Posted in Treating Chronic Illness Series

Lithium — the next step

This is the third article in a series called Treating Chronic Illness that started at the beginning of January 2016. For background information about methylation and MTHFR, download The Methyl Group: What It Can Do for You found on the home page of www.NancyMullanMD.com. For previous articles in this series, and all previous informational posts by Dr. Mullan, look at http://www.nancymullanmd.com/blog.

So now, things going as hoped, you have started broad support of methylation by using Dr. Amy Yasko’s All in One multivitamin, and the shortcut support afforded by DHA and Phosphatidyl Serine. You do not want massive doses of DHA, 200 – 300 IU being all that is usually necessary for this purpose. Lipids slow down the Nitric Oxide Synthase (NOS) enzyme that works in the kidney to help excrete toxins, so hold lipids to moderate levels. This includes liposomal supplements also.

The Phosphatidyl Serine you use should be formulated similarly to Dr. Amy’s product found at www.HolisticHeal.com (SKU# 01043). There are a lot of Phosphatidyl Serines out there.  They all have very different formulations. Nature’s Way has a product that is similar to Dr. Amy’s.

At this point, you want to start thinking about lithium. Lithium is important for a number of reasons. They are detailed in older posts that you will find on the blog mentioned above. The big deal for our purpose is that lithium enhances the uptake of B12 into the cell. You need B12 in your cell to make methyl groups. Methyl group formation happens in the cells of the liver, kidneys and brain.

If you get a serum B12 and it is high, don’t freak out. It most likely means your lithium levels are low. B12 is completely non-toxic, so don’t worry about it. Don’t go on a rampage to lower your B12. Get a serum lithium level, or use hair and urine testing to determine what it is.  Standard serum lithium blood tests show the correct ranges even for people who are not taking pharmaceutical lithium. You may be low.  You may be below detectable range. Many people with chronic illness are low in lithium, and people with MTR + will dump it.

When you start taking lithium, you may see a reaction, especially if you are sensitive to supplementation. By supplement reaction, I mean any symptom that starts as soon as you start taking a particular supplement or shortly thereafter. You know and recognize it because you have started supplements one at a time and have learned how to figure out when something you started taking is having an impact.

Start with a very low dose of lithium so that if you do have a reaction, it is not a big one. It will pass. Keep the amount of any supplement that gives you a reaction low. Be sure that you know the difference between a reaction from a supplement that is beneficial versus a reaction that means that you should not be taking that particular supplement. More on this next week…

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity. 

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
 
International access numbers are linked here.
 
Join us to inform yourself so that you can be proactive about your health!

Methylation_Pathway1

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…
JB

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818) 954-9267

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

Posted in Treating Chronic Illness Series

Everything I Know About Treating Chronic Illness In Bite Size Pieces…

Last week’s email was the start of a series that will detail how I proceed into a treatment, what I am thinking at each step.  It will be cut down into ‘bite sized’ pieces, so you are not overwhelmed with information and get your best chance at understanding the information.  For an explanation of the basic biochemistry that I am talking about, go to www.NancyMullanMD.com and opt in for the e book that you will find on the home page there. To reread last weeks email click here.

This is the second email in the series. Last week I dealt with putting in all of the basic nutrients to get methylation going by using All in One, Dr. Amy Yasko’s  multi vitamin/mineral. and by pushing the ‘shortcut pathway’. Most of you can tolerate this. If you cannot, then you have to figure out what your body needs by testing and be sure to include it in your program.

Sometimes it will happen that something you need produces such a reaction when you take it that you have to back off, let your system calm down, and start by introducing such infinitesimal amounts of it that you have only a very minimal, very tolerable reaction. You may be able to work up from there.

Or you may find that you are stuck. You may be totally unable to take a nutrient that is essential to this protocol without a giant uproar from your body. Then you just have to work around it until you figure out why this is happening from testing.  Sometimes as you get other pieces of the program into place, your reactivity to a certain element lets up. You may have to deal with some underlying issue, your GI tract for example, before you can tolerate the other nutritional support that you need.

If you are reacting to absolutely everything and you cant get a break, then you need to test the water supply to your house. The laboratory I like to use for this is Micro Trace Minerals from Boulder, CO. The other possibility is that there is mold in your environment. Don’t just assume that your environment is OK. Test it. More than a few people have spent a year or more trying to add supplements only to discover later that the source of their reactivity was an environmental factor that could have been eliminated at the start of their program.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity. 

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
 
International access numbers are linked here.
 
Join us to inform yourself so that you can be proactive about your health!

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…
JB

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA  91505
Telephone/Fax: (818) 954-9267

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

Posted in Treating Chronic Illness Series

New Years Resolution: I will make these emails short, understandable, and relevant clinically…

Starting out, if you have mutations in your methyl group producing pathways, it is important to get your methylation cycle moving again to produce methyl groups. This enhances your immunity and provides regulation of your genetic material. It enables the myriad reactions that methyl groups perform in your body. It is faster and provokes fewer unwanted reactions to induce activity in your BHMT pathway first. This is the pathway that goes directly from homocysteine to methionine in the image below.

Methylation_Pathway1

If this is confusing to you, go to the home page of my web site, www.NancyMullanMD.com, and download the e book you find there. Chapter three describes the basics of what I am talking about. It takes some repetition to finally grasp and use these concepts.

Over time, when you are able to support MTR, MTRR and MTHFR C677T mutations so that the long way around the cycle can function properly, then your body will not need to rely as heavily on the shortcut through the BHMT enzyme.

There are advantages to supporting so that you are able to go around the cycle, that is to use the “long route”, as well as the “short cut”. As a result, it is important to supplement with low doses of a range of supplements that support all of the weak points of the methylation cycle. So Dr. Amy developed All in One, her basic multivitamin. It is the first vitamin you try, unless you know you cannot tolerate multivitamins, or there is something in it that you definitely should not be taking. You start out with a tiny amount of it, something like the amount you can fit on the broad end of a toothpick. You stay at that amount until you have clarity about what increasing the amount will be like. You do not have to get up to any particular dose. Most people have no trouble with it and can easily get up to 3 caps per day.
 
The next thing to add is DHA, the fish oil, docosahexaenoic acid. You are not using massive doses of this, 200-300 IU per day. Do not take a lot of EPA, eicosapentaenoic acid, the fish oil usually found with DHA. Do not take more EPA than DHA. Most people tolerate DHA really well. If you know that you are sensitive to supplements, start with a tiny amount, like one drop, and work up. DHA pushes the shortcut route, the BHMT pathway.
 
Next you would try to add some Phosphatidylserine Complex, or PS/PC/PE, as Dr. Amy has formulated it. This also pushes the shortcut pathway. Use Dr. Amy’s formulation, the one found at www.HolisticHeal.com. It is SKU# 01043. It is a soft gel cap. Pierce the cap and start with a tiny amount if you are sensitive to supplements. Start slow, see what happens.

This is a foundation for methyl group production. It is just the beginning. You will be introducing other supplements as testing and your clinical condition indicate. Your gastrointestinal tract usually needs to be addressed, and you may have issues with mitochondrial function and/or fatty acid metabolism. My plan is to continue walking you through each of these areas, telling you how I work and how I think to undo some of your confusion. It is not simple, it is not kitchen medicine. You do need guidance. My Tuesday night Open Forum is there to help you.

It is up to YOU to learn about treating your chronic illness successfully…

You need to know about the role of optimizing both methyl group production and your capacity for methylation in order to be healthy.

This is your opportunity.

My Tuesday evening calls are ongoing.

They happen every week. There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
 
International access numbers are linked here.
 
Join us to inform yourself so that you can be proactive about your health!

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…
JB

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MD

Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank CA  91505
Phone/Fax: (818) 954-9267

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

Posted in Treating Chronic Illness Series

Open Forum Invitation

My Tuesday evening calls are ongoing through December 15th.
After that, we break for the holidays.

Dr. Mullan would like to invite you to her Open Forum which is held on Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information.

The call in number is (605) 562-3140, and the access code is 691392#.

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

Join us to inform yourself so that you can be proactive about your health!

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS

Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic…
JB

JOIN US ON TUESDAY NIGHT!

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD

Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

Posted in Uncategorized

Critical Keys To Getting Over Psychiatric Symptoms

 Keep Methylation Central

There are few things that destroy your life as immediately and completely as the cognitive function loss involved with neuropsychiatric syndromes.
 
I am Dr. Nancy Mullan. I help people who have mental function disability because of psychosis or a mood disorder, who want to feel their heads and lives quit swirling, and make progress toward their most important goals.

This discussion concerns the neurotransmitter dopamine. Dopamine is responsible for attention, motivation, and reward motivated behavior. It is an important neurotransmitter. It is the predominant neurotransmitter in your pre-frontal cortex (PFC).
 
Cognitive behavior is processed in your PFC. It is where your executive function resides. It’s the brain power you use to cross the street,  the mental apparatus that you need to make decisions. It’s the seat of your personality, the home of all the characteristics that make you you.
 
The levels of dopamine in your PFC determine how well it functions. All of the genes and the biochemical pathways that impact these levels are tremendously important to your cognitive function.
 
One of these genes is the catechol O-methyltransferase (COMT) gene. The COMT gene is named after the enzyme. The COMT gene encodes the production of the COMT enzyme.
 
Catechol-O-methyltransferase, the enzyme, deactivates dopamine. So both the gene and the enzyme are very involved with the level of dopamine in the brain, and both are important to cognitive processing.
 
A SNP in the COMT gene decreases the activity of the COMT enzyme, so less dopamine gets deactivated. As a result, the dopamine levels in the brain may become higher than optimal.
 
Methyl groups are needed to deactivate dopamine. When the COMT enzyme is less active, fewer methyl groups are used. COMT deactivates less dopamine and uses fewer methyl groups to do so. Your methyl group production and supplementation needs to be less.
 
Too much methyl group supplementation with a slowed down COMT enzyme can generate depression and mood swings in adults. In children, the symptoms are hyperactivity and stims, among others. Too many methyl groups in your body is a chemical stressor and a tax on your adrenal glands.
 
Besides having a connection with depression and mood swings, COMT SNPs that slow down enzyme function have been associated with bipolar disorder, schizophrenia, and ADHD. Studies show that COMT enzyme slowdown related to COMT gene SNPs impact executive function, working memory, verbal fluency and intelligence.
 
Too much dopamine results in intense, psychotic anxiety. Your thinking processes go off, you are ‘not right’. Anti-psychotic medications are all dopamine antagonists. Too much dopamine is very intimately associated with psychosis.
 
Dopamine is also an important catecholamine, a class of amino acid that includes nor-epinephrine and epinephrine. These are all excitatory neurotransmitters. Too much of any one of these is over stimulating.
 
It is only common sense that you should know your COMT status so you can adjust your methyl group intake to accommodate it, especially if you are having symptoms or ‘psychological’ problems.
 
Lithium has been used for psychiatric disorders for more than fifty years. Its mechanism of action is still unknown. Lithium has many functions in the body, and it has a key function in the formation of methyl groups.
 
B12 and folic acid are essential to methyl group formation, and lithium is critical for the uptake of B12 and folic acid into the cell, which is where the formation of methyl groups happens. Methyl groups are made inside the cells of the liver, kidneys and brain.
 
Beyond that, lithium may increase the production of the COMT enzyme. So no matter what the status of your COMT gene is, lithium can help to assure that you have enough COMT enzyme to process dopamine and other catecholamines.

There are things you should be doing for psychiatric problems other than taking pharmaceuticals and hoping for the best.

Psych patients have been demonstrated to have the same issues that are seen in other adults with chronic illness.
 
You may be dealing with immune impairment, gastrointestinal disorders, persistent bacterial and viral infection, yeast infestation, multiple food sensitivities, and heavy metal toxicity. You cannot afford to sit around, take meds and attend day care while your life passes. Your time is too valuable, your life is too precious.
 

  • Are you ready to discover the role of genetics in your health issue?
  • Have you had it with your mood?
  • Do you believe that you have had all the help there is out there?

 
I know that you have not.

Read the materials I have put out on optimizing diet, supplementation and methylation capacity. They can be accessed at www.NancyMullanMD.com and https://chronicdiseaserecovery.wordpress.com/ Get familiar with all of the conditions that optimizing these factors can correct.
 
You need to know the status of all of the genes encoding for the enzymes in your methyl group producing pathways, so you can bypass any problem genetics, and be sure you have the methyl groups you need to perform all of the important functions that involve methyl groups, including keeping your dopamine at optimal levels.

It is up to YOU to learn about treating psychiatric illness successfully, and the role of optimizing both methyl group production and your capacity for methylation.

This is your opportunity.

My Tuesday evening calls are ongoing. They happen every week. There is no charge to come on this call. It is a free forum where you can ask your questions. I am there to help you, and I have a group of experienced patients who will give you their insights also.
 
It’s a great way to answer your most pressing questions, clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

My Tuesday evening calls are ongoing through December 15th. After that, we break for the holidays.

There is no charge to come to the call.  It is a free forum where you can ask your questions.  It’s a great way to clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
 
International access numbers are linked here.
 
Join us to inform yourself so that you can be proactive about your health!

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB
 
You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL

Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS
 
Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

This is brilliant.  I hope a lot of people not doing methylation work will see this.  I wish I’d seen this before I started doing daily injections of B12 and folic acid and ended up in a crisis. Maybe had I known to have the genetic methylation stuff going, the IV therapies I did that really helped would not have been so traumatic… 
JB

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MD
 
Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.
 
2829 Burbank Blvd., Suite 202, Burbank CA  91505
T: (818) 954-9267 – F: (818) 954-0620
 
NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog
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