Dr. Amy Yasko on Allergic Reactions and Mast Cell Activation Syndrome

Mast cells, basophils, and eosinophils are the cells that generate an allergic reaction. Allergens binding to these cells cause the release of histamine, which causes immediate, and sometimes very intense, hypersensitivity reactions.
 
Mast cells are like water balloons filled with histamine. When your body reacts to an allergen, it is like sticking a pin in the water balloon, allowing histamine to burst out. Mast Cell Activation Syndrome (MCAS) is a condition in which excessive numbers of mast cells are triggered even in the absence of a specific allergen. The goal is to both reduce the number of mast cells, as well as to mitigate the high histamine levels.

Low tetrahydrofolate (THF) levels can cause elevated histidine. Elevations in histidine in turn cause increased levels of histamine. So, high histidine along with high histamine may indicate a need for THF. The FIGLU on a Metabolic Analysis Profile Test (MAP Test) will also climb If there is not sufficient THF. Thus, high FIGLU may be an indirect sign of excess histidine.

The methylation cycle is also important in processing the histamine that is produced secondary to a lack of THF. FIGLU is an indicator for low THF. When FIGLU is elevated it leads to the formation of histidine, which can convert to histamine. You need methyl groups to process histamine.
 
Histamine is broken down by the enzymes diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). The HNMT enzyme requires methylation cycle function in order to break down histamine. The DAO enzyme needs copper to function. High levels of copper can be an issue for other neurotransmitters, increasing the breakdown of serotonin and dopamine, as well as negatively impacting attention. So, the goal is to keep copper in a normal range, with zinc levels higher than copper. In this way, there is sufficient copper for DAO function without causing increased serotonin or dopamine breakdown or causing issues with attention.

You may be able to slow down some of the mast cell degranulation and histamine release of an IgE reaction by the use of quercetin. Quercetin is not optimal for those who are COMT + +. While it may be a help for high histamine, as well as for oxidative DNA damage, it is not ideal for those who are COMT ++ because it can inhibit COMT.  Cherries are a natural source of quercetin, so while cherries may help with inflammation, gout, and some forms of arthritis, the quercetin levels in cherries may be an issue for those who are COMT ++. Also, Butterbur, which is in Petadolex, blocks the action of histamine.
 
Finally, more traditional medications may be a help if natural approaches are not enough to address severe MCAS. The antibiotic minocycline has been reported to limit certain inflammatory reactions and can be used for anti-inflammatory purposes rather than for its antibiotic properties. Minocycline has been a help for limiting excessive microglial activation that plays a role in chronic neurological inflammation.

In addition, minocycline has been reported to reduce overall levels of IgE. The action of IgE specific allergens binding to mast cells allows the massive release of histamine in allergic conditions. Limiting IgE levels while identifying and eliminating the allergic triggers may be a help in extreme conditions in which natural approaches have not been sufficient.
 
The combination of Claritin and Pepcid has been reported to lower the number of mast cells in skin reactions, as well as to decrease histamine levels. While Dr. Amy generally prefers to go the more natural route first, to work on the underlying causes, in extreme conditions of MCAS, the combination of medication with natural supplements may be considered.
 
Excerpted from Chapter 16 of Feel Good Biochemistry which can be accessed at www.feelgoodbiochem.com

It is up to YOU to learn about treating chronic illness successfully.

You need to know about the role of optimizing both methyl group production and your capacity for methylation.

This is your opportunity.

My Tuesday evening calls are ongoing.  They happen every week.  There is no charge to come to the call.  It is free forum where you can ask your questions.  It’s a great way to clear up confusion, overcome the obstacles you may be having, and get on the path to wellness.

The time:  Tuesday at 5:00 PM Pacific Time

(8:00 PM Eastern, 7:00 PM Central, 6:00 PM Mountain)

The number to call in the US: (605) 562-3140

The access code: 691392#
 
International access numbers are linked here.
 
Join us to inform yourself so that you can be proactive about your health!

So excellent!  I literally learn something on every single call and I get clarification on things that have been lingering on my mind…
VB

You are giving people a huge gift by empowering them…It’s about helping the patient become their own healer by taking them to a higher level of consciousness…
AL
 
Thank you so much Dr. Mullan.  Thank you so, so much for everything you do.
MS
 
Wow!  I have to tell you, this was such an uplifting call.  It’s so nice to hear good news especially about a child.  Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me.  So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!!
TR

JOIN US ON TUESDAY NIGHT!

Nancy Mullan MD
 
Author, lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.
 
2829 Burbank Blvd., Suite 202, Burbank CA  91505
T: (818) 954-9267 – F: (818) 954-0620
 
NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog
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Lithium — Pivotal In Your Recovery!

Lithium has been known for years to be useful for bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact. It is likely to be an effect on multiple pathways, since there are a number of enzymes in the body that are known to be impacted and inhibited by lithium.

Lithium comes together with methylation at COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down dopamine and nor epinephrine. Dopamine is a critical neurotransmitter for motivation, focus and attention, among other functions. Nor epinephrine is involved with modulating the impact of stressors. Both are central to nervous system function.

COMT uses methyl groups to accomplish this deactivation. COMT – – breaks down dopamine at a steady even rate and uses significant numbers of methyl groups. COMT ++ breaks down these neurotransmitters more slowly and uses fewer methyl groups.

We know that giving a patient more methyl groups than they can use produces symptoms. They get mood swings and start to look bipolar. Children will become hyperactive, ‘stimmy’ or get other symptoms when they are put on methyl B12 if it is too much for them.

Lithium may inhibit the production of a central enzyme in the sulfur system, thioredoxin reductase. It appears that lithium may be increasing the production of COMT and inhibiting the production of thioredoxin reductase. COMT and thioredoxin reductase have genes that are on opposite strands of chromosome 22. Their promoter regions overlap which implies some mutual regulation. Having a shared promoter means that at any given time you can make either COMT or you can make thioredoxin, but you cannot make both.

This circumstance is analogous to a roadway being closed down to one lane. The line of traffic can move only in one direction at a time. One lane is stopped while the other one can go. A shared promoter generates the same situation in gene transcription. You can make either COMT or thioredoxin, but not both at the same time.

Dr Amy emphasizes that this is her hypothesis, it is not scientific fact. But based on this hypothesis, she started looking carefully at lithium levels and opened up a whole new area in her program. Using this hypothesis makes a difference for patients. She noticed that MTR+ is associated with excess lithium excretion. An out of balance methylation cycle will also cause increased lithium excretion. The vast, vast majority of patients using this protocol come in with low lithium levels.

Dr Amy suggests only low dose lithium support because lithium also inhibits ribonucleotide reductase. Ribonucleotide reductase takes ribonucleotides, ie, RNAs, and breaks them down into building blocks for DNA and other RNAs. So one of the toxic impacts of high dose lithium is this impact on RNA breakdown. You need to support with DNA building blocks, for example using Nucleotide Immune Support. The RNA formulas also supply these building blocks.

Lithium is an essential trace element. You must get it from your diet. The average intake of lithium from the diet should be up to 3100 mcg, or 3.1 mg. Dr Amy wants to supplement with very low level lithium, around 2.5 mg. She wants to do it consistently and she does not want to get near biologic doses. What it takes to actually increase a patient’s lithium levels can be significantly more, especially with sicker patients.

You have to keep watching the lithium and cobalt levels on a UEE. High lithium levels on a UEE may indicate excess excretion, but when cobalt, the oxidized form of B12, starts to show, you know the lithium level is coming into balance and you can start to push the long route instead of just the short route.

Why is this important?

There is a connection between lithium and COMT, bipolar disorder and schizophrenia (SZ). It is possible that imbalances in the COMT pathway need regulation by low dose lithium in order to get the kind of levels of COMT that you need for proper dopamine processing. When the levels of COMT in the brains of patients with SZ and bipolar disorder were compared with normal controls, the levels of COMT in those affected were lower than in controls. Lithium seems to increase the activity of COMT.

Lithium induces B12 transport into the cells thus driving the long route. This can happen with just the standing levels of B12 without additional supplementation. B12 binding capacity as well as white count will go up in the presence of lithium. B12 deficiency is known to lead to degeneration of the central nervous system and psychiatric disturbances such as affective disorders and manic psychosis. Violent criminals as a group have the lowest levels of lithium in hair. There is not only a relationship between lithium, B12 and folate, but also between low lithium and anxiety, aggression, bipolar disorder and SZ.

In studies with patients known to be low in B12, the following psychiatric manifestations were reported to remit with vitamin B12 therapy: confusion , hallucinations, delusions, disorientation, confabulation, anxiety, restlessness, fatigue, depression, irritability, sleepiness, psychosis, stupor, slowed ability to process thoughts, decreased memory, acute delirium, mania, apathy, lack of energy, weakness, violent behavior, flight of ideas, negativism and acute paranoid states. These symptoms may occur in the absence of hematological evidence of B12 deficiency.

So certain behavioral problems, depression and learning disability could be caused or aggravated by low nutritional intake of lithium coupled with marginal deficiencies of B12.

Lithium has a direct effect on nor epinephrine pathways. Lithium indirectly inhibits thioredoxin reductase. There is an inverse relationship between thioredoxin reductase and COMT, so it may be that lithium increases COMT leading to decreased nor-epinephrine.

Other positives of lithium:

Lithium stimulates tyrosine hydroxylase, which is a secondary pathway to dopamine production.

Lithium has neuroprotective actions against a variety of insults. It increases GABA activity. It helps to protect against glutamate excitotoxicity by inhibiting the NMDA receptor induced calcium influx.

Lithium plays a role with sodium and potassium balance.

Lithium may help to repair neurons and reduce some of the trauma after injury.

It induces enhancement of mitochondrial oxidative phosphorylation in human brain tissue.

It plays a role with respect to myelination by enhancing the expression of brain derived neurotrophic factor.

And finally, lithium has been shown to be protective in Alzheimer’s disease.

Lithium and thyroid.

Lithium has an impact on thyroid hormone production because it competes with iodine for uptake from the GI tract. We suggest getting around this problem by painting a 2’’ square of iodine on your skin and watching how long it takes for your body to absorb it.

If it is gone in 1 hour, you need iodine. Keep painting it on daily for transdermal supplementation.

If it stays on for 24 hours, you have enough iodine in your system. You can extrapolate the times between those two limits. Given all that has been said about the positives of using lithium if you are low in it, it is best not to just toss it aside because someone told you it was bad for thyroid. You may need both lithium and iodine. You can get both in the way just described.

Dr. Mullan would like to invite you to her Open Forum which is held on Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information.

The call in number is (605) 562-3140, and the access code is 691392#. 

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

Thank you for your interest in Dr. Mullan’s work.

Nancy Mullan MD

Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

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Make no mistakes about MTHFR and brain function

Keep Methylation Central

To understand attention, attention based learning, motivation, pleasure, and the other functions of the neurotransmitter dopamine, you have to know something about D4 dopamine receptors. And critical to the function of dopamine receptors is the MTHFR C677T gene and enzyme.

Picture

The function of the D4 dopamine receptor depends upon the cell membrane in which they are embedded. 

The membrane surrounding your cell, the plasma or cell membrane, is represented above by a three dimensional fluid mosaic. It is composed of a bi-lipid layer, a double layer of lipid or fat, which has a head at one end. The lipid is actually phospholipid.

Nerve cells also have a phospholipid cell membrane. In this depiction, the head is represented by the red, green, purple, and lime green rounded structures. Anyone who has listened to the Tuesday night calls has heard me talk about phospholipids at length.

Phosphatidyl serine complex is the important shortcut support that almost everybody starts out on. It is a complex of the same phospholipids in the nerve cell wall.

Receptor sites are positioned in the cell membrane. They are represented by pink lobed molecules with antenna-like structures projecting out of them. The antenna-like structures grab the appropriate molecule for the type of receptor involved and transport it into the cell.

The cell membrane must be fluid. It can’t be rigid. If it is too rigid, the molecules in the membrane can’t move or function properly. They need to be able to move in order to signal appropriately.

Some receptors function by totally inverting into the cell. They invert and pull the substance into the cell by doing so. You cannot have a stiff, inflexible cell membrane and do this effectively. That is what is wrong with trans fats: they are too stiff.

The receptor I am focusing on today is the D4 dopamine receptor. Dopamine is the neurotransmitter responsible for attention, motivation, pleasure and reward motivated behavior. It is an extraordinarily important neurotransmitter because it is the predominant neurotransmitter in your pre-frontal cortex.

Cognitive behavior is processed in your pre-frontal cortex. It is where your executive function resides. It’s the brain power you use to cross the street, the mental apparatus that you need to make decisions. It’s the seat of your personality, the home of all the characteristics that make you you.

The D4 dopamine receptor is responsible for attention and attention initiated learning. It operates by inverting into the cell. A very fluid cell membrane is necessary to do this. Without this fluidity, you may get a diagnosis of Attention Deficit Disorder or Attention Deficit Hyperactivity Disorder.

Dopamine activation of the D4 receptor initiates a cycle of phospholipid methylation. There is actually a methionine cycle which produces methyl groups attached to this dopamine receptor.

Picture1

 

Depicted above is the bi-lipid layer of the phospholipid cell membrane. The oval structure is a representation of a receptor site which is made of protein.

On the left side, there is no phospholipid methylation. There are no methyl groups between the heads of the molecules in the membrane.

When there is a space made by the methyl groups between the phospholipid heads, there is more room for the receptors to be able to move and function. It is a more fluid membrane. The protein receptor will be able to move around better and will be able to signal and react with other proteins more easily.

Inadequate methylation negatively impacts your ability to attend and learn. The dopamine receptor needs to be able to reconfigure itself. It needs to be able to invert itself into the cell and then come back out again. It is not able to do that if the membrane is inflexible. 

Phospholipid methylation, the addition of a methyl group to phospholipids, reduces the packing density of the membrane and enhances the activity of embedded, integral membrane proteins like the D4 receptor.

The D4 receptor has a methylation cycle associated with it. The activity of this methylation cycle is affected by the availability of 5 methyl tetrahydrofolate (5 MTHF). When the level of 5 MTHF is decreased, it becomes a limiting factor. The receptors wait for a new methyl group to start the activation. Receptors sitting around waiting for methyl groups greatly reduces the impact of any dopamine present. Even very high amounts of dopamine that may be present will not activate the receptor if there is too little 5 MTHF.

And what determines 5 MTHF availability? The function of MTHFR gene and the enzyme for which it encodes. These are critical for an adequate supply of 5 MTHF. MTHFR 3 is even a more profound genetic down regulation of enzyme activity than MTHFR C677T. So proper function of MTHFR or appropriate supplementation of 5 MTHF are necessary for the function of dopamine which is critical for good brain function. 

There is more information on methyl groups and methylation on my web site at www.NancyMullanMD.com and on my blog at www.NancyMullanMD.com/blog.

My Tuesday night call is your chance to learn what you need to know to get this important area of your life and biochemistry under control. I take your questions on many topics, among them the impact of your personal genetics on your biochemistry. I discuss how to balance your biochemistry with nutritional supplements that bypass problem genetics.

It is up to YOU to learn about treating psychiatric and other chronic illness successfully.

You need to know about the role of optimizing both methyl group production and your capacity for methylation.
 
This is your opportunity.

Dr. Mullan would like to invite you to her Open Forum which is held on Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information.

The call in number is (605) 562-3140, and the access code is 691392#. 

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

JOIN US ON TUESDAY NIGHT!

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD
 
Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.
 
2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620
 
NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

 

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The Great Folate Debate

Since 1959 it has been known that folic acid deficiency results in the inability to degrade formiminoglutamic acid (FIGLU), so that FIGLU accumulates in your body and is excreted in your urine. The Metabolic Analysis Profile test (MAP test) uses this principle to assess your folic acid sufficiency. Your FILGU levels are measured and high levels suggest a need to use low dose folate and folic acid support.

It is important to use both folic acid and folate supplementation for several reasons. The first is the pathway that involves MTHFS, an enzyme in the methylation pathway. MTHFS functions in the folate cycle, where it catalyzes a reaction that turns formyl tetrahydrofolate, or folinic acid, into tetrahydrofolate (THF), or what you ordinarily think of as folic acid.

MTHFS also impacts the formation of guanine and adenine, two purines that are necessary for DNA and RNA formation, the formation of fast turnover cells like blood cells or GI tract lining, and wound healing. If you have a mutation that reduces MTHFS activity, folinic acid can build up to high levels, your synthesis of guanine and adenine is reduced, and your tetrahydrofolate level is also decreased.

Dr. Amy Yasko’s program uses low dose folinic acid to prevent its build up, adds guanine and adenine to support DNA and RNA production, and uses low dose folic acid along with probiotics as a secondary way to make THF. In this way, the impact of any possible MTHFS mutation is bypassed, even if you do not have data regarding this gene.

Dr. Amy wants to consider all aspects of a particular pathway when adding support. She chooses to add only low dose folinic acid to keep the levels of folinic acid from climbing, which could happen if you are adding high dose folinic acid and have a MTHFS mutation. She adds guanine and adenine to supply purines in case the pathway for their formation is not fully functional. She adds low dose folic acid to have a secondary route for making THF, a route that also consumes excess glutamate.

The rationale behind adding low dose 5 methyl THF also is that the way to bypass an MTHFR C677T mutation is with 5 methyl THF. No amount of folinic acid, folate, or folic acid is going to bypass a MTHFR C677T mutation. Folate will not bypass MTHFR. 5 methyl THF is the only way to bypass MTHFR C677T.

Using high dose 5 methyl THF at the beginning of a treatment for MTHFR + can trigger more detox than you can handle, especially if you are an adult. You may need to supply your body with nutritional groundwork and ease into 5 methyl THF administration.

Folate is basically a chain of glutamates. The difference between folic acid and folate is the stability and the length of their glutamate chains. So, if you are MTHFR C677T++ and you take high dose folate, you potentially have a chain of unused glutamate molecules left in your body. You cannot process it efficiently to 5 methyl THF because of your mutation. You run the risk of folate breaking down to release glutamate into your system.

Folic acid has a shorter glutamate chain than folate. Folic acid is also more stable, so it is less likely to break down into glutamate. Dr. Amy uses only a tiny bit of folic acid, to allow FIGLU to convert into glutamic acid. Most of the folate that is used for Dr. Amy’s program is 5 methyl THF, with some low dose folinic acid.

Dr. Amy has specific reasons for the choices she makes in terms of supplements and the forms that she uses. The RDA for folate/folic acid is 300 micrograms for a child that is 1 year old, and up to 1,000 micrograms daily for an individual 19 years of age or older. Thus the 15 to 40 micrograms used for her program is not an issue, especially since the body does need some folate and folic acid aside from the need for 5 methyl THF and folinic. To put this in an easily understandable perspective, a bowl of cheerios has 400 micrograms of folic acid, as compared to the 15 to 40 micrograms used in her program.

High levels of the enzyme urocanase will also increase FIGLU. Urocanase is produced by certain bacteria, including Pseudomonas, so consider stool testing when high FIGLU is noted on a MAP. Urocanase is limited by succinate. Be sure that succinate levels on a MAP test are in balance, because a lack of succinate combined with bacterial increases in urocanase can be factors in high FIGLU as opposed to a need for folate.

This information has been excerpted from Dr. Amy’s online book Feel Good Biochemistry, that can be found at www.FeelGoodBiochem.com.

Dr. Mullan would like to invite you to her Open Forum which is held on Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information.

The call in number is (605) 562-3140, and the access code is 691392#.

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded. International call in numbers are linked here.

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD

Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank, CA 91505
T: (818) 954-9267 – F: (818) 954-0620

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

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How much do you know about oxalate?

A number of programs and tests focus on high oxalate, which is also called oxalic acid. Dr. Amy Yasko’s program integrates the issue of high oxalate into a larger concern about overall biochemical balance. The most frequent response to high oxalate is the implementation of a diet low in oxalate foods. This is the quickest way to get oxalate down in the short run. However, there are a number of factors that may trigger high oxalate levels. A determination if the trigger is, for example, high yeast or fungi, a lack of B12, or low ATP, is made through interpretation of testing. The reason for the high oxalate then guides your decisions as to how you address the problem.
 
High oxalate may be due to yeast and fungal infestation. These factors can be investigated with stool testing and appropriate action taken.
 
High oxalate can also be caused by low B12. Low B12 makes the Krebs Citric Acid energy cycle run in a reverse direction, which increases oxalate. Check serum B12 or cobalt levels. Keep in mind that many people with chronic health issues turn out to be low lithium. Lithium transports B12 into your cells. If your lithium is low, your B12 and/or folic acid may appear high on serum testing. They are not getting transported into your cells, so high values for these two critical nutrients may indicate that you need to supplement with nutritional lithium.

The Krebs cycle is the energy/ATP  generating function of the mitochondria in your cells. Your level of B12 impacts enzymes in the Krebs cycle, and the levels of Krebs intermediates are affected. Oxalate is a Krebs intermediate. Conditions of B12 deficiency, coming either as a result of mutations in the methylation cycle, and/or by high level depletion of B12 through endurance training or sports, can lead to increased levels of oxalate. High levels of tartrate in the absence of high arabinose, or high levels of fumarate, should lead you to consider supplementing with multiple forms and routes of B12. This includes chewable hydroxyl, adenosyl, and methyl B12. The relative amounts depend on your Nutrigenomics.

If you have high oxalate levels, you should consider increasing your B12 support. Other supplementation also aids in the productive conversion of oxalate.
 
The levels of certain amino acids may indicate high oxalate. There are three branched chain amino acids, leucine, isoleucine and valine. High leucine in the absence of high valine or isoleucine can occur secondary to low phosphate. This may also cause increases in oxalate, so check to determine if leucine is high and what your phosphate levels are. High oxalate may also be due to excess glycine secondary to SHMT + or excess iron. If threonine is high, this may be an indication of high oxalic acid.

High levels of citrate or high levels of the intermediates that precede acetyl CoA on the Metabolic Analysis Profile diagram, i.e., pyruvate, lactate, etc., may be an indirect indication of high oxalate, as the cycle is not incorporating at 11:00 (oxalate) well enough to be moving around to 1:00 (citrate) properly. Also, a build up at 1:00 (citrate) may be causing a backup in the cycle, which may be an indirect indication of high oxalate.
 
Aluminum and thallium can impair the function of the Krebs cycle, so address thallium and aluminum if they are found to be elevated.
 
This information has been excerpted from Dr. Amy’s online book Feel Good Biochemistry, that can be found at www.FeelGoodBiochem.com.

Dr. Mullan would like to invite you to her Open Forum which is held on Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information.

The call in number is (605) 562-3140, and the access code is 691392#.

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD
 
Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.
 
2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620
 
NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

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So, what’s the big deal about lithium anyway?

The role of lithium in B12 transport into the cell is critically important.  Peer reviewed work by Tisman, Herbert, and Rosenblatt, published in the British Journal of Haematology, was the first to illustrate that ingestion of lithium is related to B12 binding, B12 binding being necessary for methyl group formation.

Continuing this research, Vanyo and coworkers in Lithium in Biology and Medicine, discuss the finding that lack of lithium and B12 deficiency share physiological features. Supplementation with lithium enhances B12 transport into cells. According to these researchers, lithium is associated with elevated levels of serum B12 binding capacity. Furthermore, this group was able to show that lithium increases the transport of folate into the cell, as well as that of B12.

Additional peer reviewed work by Schrauzer, Biological Trace Element Research, also supports the role of lithium in B12 transport. The addition of lithium was shown by these researchers to lower elevated serum B12 levels, again illustrating lithium’s effecting B12 transport into cells.

Based on this research, it is important to know your lithium levels. When lithium is low and/or serum B12 is particularly high, use lithium supplementation prior to adding more B12. Increasing B12 in the absence of lithium may further deplete lithium levels due to the use of lithium to aid in the transport of the added B12. Ideally, lithium should be in balance prior to adding excess B12 so as not to create lithium depletion.

Lithium plays a range of additional roles in your body aside from B12 and folate transport into your cells, so it is important not to deplete this pivotal trace mineral. Lithium’s impact on mood stabilization has been known and used clinically for many years, despite the fact that the mechanism by which this occurs has not been fully elaborated. Norepinephrine imbalances have been implicated in attention disorders, and researchers have illustrated an impact of lithium on balancing norepinephrine levels.

Researchers have noted and published effects from lithium on neurological conditions. Beta amyloid may play a role in Alzheimers Disease, and lithium has been shown to have neuroprotective effects against beta amyloid.  Research from Spain illustrates that lithium has a positive impact on neural repair after traumatic injury. Other research shows that lithium can enable mitochondrial function.

A need for support for the mitochondrial energy cycle may also be seen with low lithium. Support for mitochondrial energy production can include Mitoforce, ATP, Riboflavin 5 phosphate, NADH, and Krebs minerals.

(Excerpted from Feel Good Biochemistry by Dr. Amy Yasko. http://www.FeelGoodBiochem.com.)

Dr. Mullan would like to invite you to her Open Forum which is held on  Tuesday night at 5:00 PM Pacific Time (8:00 PM Eastern Daylight Time, 7:00 PM Central, 6:00 PM Mountain) in order to answer your questions and introduce you to her work. You may be checking her out to see if you would like to consult her. Or you may not have the option of working with her, but would still like to get her information. 

The call in number is (605) 562-3140, and the access code is 691392#.

When you hear Dr. Mullan come on the line, press *6 to get into the question and answer line if you have a question.

This program is not recorded.  International call in numbers are linked here.

Thank you for your interest in Dr Mullan’s work.

Nancy Mullan MD

Author, lecturer, clinician
Dr. Nancy Mullan is best known for her natural treatment of chronic illness, including Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank, CA  91505
T: (818) 954-9267 – F: (818) 954-0620

NancyMullanMD@aol.com
http://www.NancyMullanMD.com
http://www.NancyMullanMD.com/blog

 

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Vaccines: Know The Risks And Failures

This article was written several years ago.  It becomes even more urgent now because of the recent tsunami of legislation removing parental rights to refuse vaccination.

By Barbara Loe Fisher
As summer comes to an end, the drumbeat promoting back-to-school vaccinations grows louder and louder in America. Unlike children in Canada and the European Union,12 our children must get dozens of doses of vaccines or they can’t get a public school education.3

No Shots, No School, No Exceptions

Over the past century, denial of a public school education has been used like a club by public health and medical trade officials demanding that state legislators enact “No Shots, No School, No Exceptions” vaccine laws.456 789101112

In 1914, children had to get one dose of smallpox vaccine to go to school.13 In 2014, children entering kindergarten must get a minimum of 29 doses of 9 vaccines.14 Babies enrolled in daycare get even more vaccines.15

Medical Exemptions Rarely Granted

Parents in 48 states can file a religious or personal belief vaccine exemption, but some states make those exemptions very hard to get.16 A medical exemption is allowed in all states, but doctors rarely grant them to children anymore because almost all medical reasons for delaying or withholding a vaccine have been eliminated.171819

Government and medical trade officials have narrowed medical contraindications to vaccination after Congress shielded doctors and vaccine manufacturers from vaccine injury lawsuits.20 Today, even children with severely compromised immune systems are given most vaccines.21

Doctors Practicing Authoritarian Medicine

Now that everybody is a candidate for vaccination all the time, liability-free doctors have been given a green light to practice authoritarian medicine.222324 Distraught parents are contacting NVIC and telling us that pediatricians are dismissing their child’s vaccine reactions as unimportant and refusing to make a report to the federal vaccine adverse events reporting system.

Mothers describe how pediatricians are screaming at them if they decline a vaccination or simply ask for fewer shots to be given to their child on the same day.25

Recently, a member of the American Academy of Pediatrics26 proclaimed publicly that he is justified in getting angry at and discriminating against parents disobeying his orders to give their children every federally recommended vaccine on schedule27 which, by the way, means 49 doses of 14 vaccines between day of birth and age 6 with 20 more doses of vaccines by age 18.28

Calling those parents “a public health menace” and comparing them to “substance abusers,” he refuses to treat their children. He said, “That person is a danger, not only to themselves but is a danger to society, a danger to other children in my practice, a danger to old people, a danger to everyone.”29

Pediatricians Exempt from Vaccine Injury Lawsuits

It is sad and frightening when doctors demonize and threaten parents making thoughtful medical risk decisions for their children. The American Academy of Pediatrics knows that vaccines carry serious risks for some children because AAP leaders successfully lobbied Congress to be exempt from vaccine injury lawsuits.3031

Some People More Susceptible to Vaccine Reactions

But even if $3 billion in federal vaccine injury compensation had not already been awarded to vaccine victims in America,32 and even if the Institute of Medicine had not published a series of reports confirming that vaccines can cause injury and death,3334353637 everybody knows that people do not all respond the same way to pharmaceutical products38 like vaccines.

Each one of us is born with unique genes and a unique microbiome39 influenced by epigenetics,40 which affects how we respond to the different environments we live in. Some of us are more susceptible to vaccine complications.4142 Public health officials have known this for a long, long time.4344

Late-Breaking News Addition to This Commentary: Girl Dies Hours After HPV Vaccination

Individual susceptibility to vaccine reactions may have been in play when 12-year-old Meredith Prohaska died within hours an HPV vaccination on July 30, 2014. According to the NY Daily News, Meredith’s mother took her daughter to the doctor for a sore throat and, while Meredith was at the doctor’s office, she was given an HPV shot.

Within 30 minutes of the shot, Meredith, who was a healthy athlete entering seventh grade, became very sleepy and slept all afternoon. When her mom came back from a short trip to get food, she found Meredith face down on the floor with purple lips and no pulse. Her mom is an EMT for the National Guard and performed CPR, but could not save her.

The initial autopsy report was “inconclusive” and further tests are being done. However, Meredith’s death is not the first to occur after HPV vaccine. By June 14, 2014, there had been 171 deaths following HPV vaccinations (Gardasil or Cervarix) reported to the federal Vaccine Adverse Events Reporting System (VAERS).

One week before Meredith’s HPV-vaccine related death, another Wisconsin teenager collapsed in her home shortly after receiving HPV and meningococcal vaccinations. Her mom reported that when her 17-year-old daughter got home after getting vaccinated, she could barely walk and collapsed, complaining of chest pain and that she was having trouble breathing. Her mom immediately took her to an Urgent Care facility and the doctors there called 911 and rushed her to the hospital ER, where she was treated and recovered.

Fox News recently discussed the Wisconsin HPV vaccine reaction cases and pointed out how difficult it is to get compensated for a vaccine injury or death. Even if parents do have enough information to understand their child has suffered a vaccine reaction and meet deadlines for filing a federal compensation claim withintwo years of a vaccine death or three years of a vaccine injury and an award is made (two out of three claimants are denied awards), compensation is capped at $250,000 for pain and suffering and $250,000 for death. There is no cap for those who require life-long care.

Learn How to Identify Vaccine Reactions

With so many pediatricians denying vaccine risks and failures, it is even more important for parents to do their own research. If your child is getting back-to-school shots, you should know how to identify symptoms of a vaccine reaction. Once your child has had a vaccine reaction, revaccination may cause a more serious reaction.45 Plus, you only have two years to file a claim in the federal vaccine injury compensation program after a vaccine-related death or three years after a vaccine injury.4647 A few of the more serious vaccine reaction symptoms are:

  • Convulsion or seizure symptoms include eyes fluttering and rolling back in the head; twitching, trembling, jerking, shaking or sudden rigidity of one or more parts of the body.48495051
  • High fever between 103 and 105 degrees F. or more.5253
  • High-pitched screamingalso known as the encephalitic cry, is described as a shrill scream, shriek, or wail that goes on for hours. Mothers often say they have never heard this type of crying before. Sometimes babies arch their backs while screaming, which can be a sign of brain inflammation.54
  • Collapse/shockThe child may be pale, have bluish lips, and suddenly go limp and appear to be unconscious.5556
  • Excessive sleepiness is when the child sleeps deeply without moving for hours after vaccination and does not respond to noise, touch, or light and cannot be easily awakened to eat.575859
  • Brain inflammationalso called encephalitis or acute encephalopathy, has been recognized as a very serious complication of vaccination since the first vaccine for smallpox. Symptoms can include convulsions, high-pitched screaming, collapse, and hours of unconsciousness.60616263646566
  • Encephalopathy or chronic brain dysfunction can include physical and mental regression, dramatic personality and behavior changes, loss of muscle control, speech, and other abilities, or the child may be unable to continue to meet developmental milestones.6768697071

Vaccine Reactions May Take A Week or Longer to Appear

This is not a full list of vaccine reaction symptoms and there are other types of reactions affecting immune and brain function involving the skin, 727374 joints,7576 blood 7778 and other parts of the body that can be warning signs a child may be sensitive to one or more vaccines. Some reactions develop within hours of vaccination while others, like convulsions following MMR vaccination, can take a week or more to appear.79

Review Vaccine Manufacturer Information and Vaccine Ingredients

Before vaccination, read the vaccine manufacturer’s product inserts so you are aware of the types of serious health problems reported in pre-licensure clinical trials and during post-marketing surveillance.80 Take a look at vaccine ingredients as well, because some children are allergic to antibiotics, gelatin, MSG, thimerosal, yeast, egg protein, and other vaccine ingredients.81,82

Vaccine Immunity Not Permanent: Pertussis Vaccine Failures

Parents also need to know that vaccine-acquired immunity is not permanent and fully vaccinated children can still get and transmit infectious diseases.83 Vaccine failures and waning immunity is a real problem for vaccines like B. pertussis,8485 also known as whooping cough. The FDA reported last year that vaccinated persons still can be infected with and transmit pertussis, sometimes without even showing any symptoms.86 The majority of children in many pertussis outbreaks have been vaccinated.8788

Learn Symptoms of Pertussis (Whooping Cough)

Signs of B. pertussis whooping cough range from a low fever, loss of appetite, and a mild cough to violent paroxysmal coughing, with choking and vomiting of large amounts of sticky mucus for many weeks.89 Small infants can suffer brain damage or die from pertussis if they cannot clear mucus clogging their airways.90 Understanding vaccine risks and failures is a vital part of conscious parenting today.

Ask Eight Questions Before Vaccination

At NVIC.org:

You can find well-referenced information about vaccines and diseases, including vaccine manufacturer product inserts, and a brochure that lists 8 questions you should ask yourself before your child is vaccinated.

  • You can review vaccine reaction reports made to the federal vaccine adverse events reporting system.
  • You can read testimonials on the Cry for Vaccine Freedom Wall by Americans describing how they are being persecuted when they try to make informed, voluntary decisions about vaccination for themselves and their children.
  • You can sign up for the free online NVIC Advocacy Portal and work to secure informed consent protections in your state’s vaccine laws.

Protect Your Right to Informed Consent and Defend Vaccine Exemptions

With all the uncertainty surrounding the safety and efficacy of vaccines, it’s critical to protect your right to make independent health choices and exercise voluntary informed consent to vaccination. It is urgent that everyone in America stand up and fight to protect and expand vaccine informed consent protections in state public health and employment laws. The best way to do this is to get personally involved with your state legislators and educating the leaders in your community.

THINK GLOBALLY, ACT LOCALLY.
National vaccine policy recommendations are made at the federal level but vaccine laws are made at the state level. It is at the state level where your action to protect your vaccine choice rights can have the greatest impact. It is critical for EVERYONE to get involved now in standing up for the legal right to make voluntary vaccine choices in America because those choices are being threatened by lobbyists representing drug companies, medical trade associations and public health officials, who are trying to persuade legislators to strip all vaccine exemptions from public health laws.

Signing up for NVIC’s free Advocacy Portal at www.NVICAdvocacy.org gives you immediate, easy access to your own state legislators on your Smart Phone or computer so you can make your voice heard. You will be kept up-to-date on the latest state bills threatening your vaccine choice rights and get practical, useful information to help you become an effective vaccine choice advocate in your own community. Also, when national vaccine issues come up, you will have the up-to-date information and call to action items you need at your fingertips..

So please, as your first step, sign up for the NVIC Advocacy Portal.

Share Your Story with the Media and People You Know

If you or a family member has suffered a serious vaccine reaction, injury or death, please talk about it. If we don’t share information and experiences with each other, everybody feels alone and afraid to speak up. Write a letter to the editor if you have a different perspective on a vaccine story that appears in your local newspaper. Make a call in to a radio talk show that is only presenting one side of the vaccine story.

I must be frank with you; you have to be brave because you might be strongly criticized for daring to talk about the “other side” of the vaccine story. Be prepared for it and have the courage to not back down. Only by sharing our perspective and what we know to be true about vaccination will the public conversation about vaccination open up so people are not afraid to talk about it.

We cannot allow the drug companies and medical trade associations funded by drug companies or public health officials promoting forced use of a growing list of vaccines to dominate the conversation about vaccination. The vaccine injured cannot be swept under the carpet and treated like nothing more than “statistically acceptable collateral damage” of national one-size-fits-all mandatory vaccination policies that put way too many people at risk for injury and death. We shouldn’t be treating people like guinea pigs instead of human beings.

Internet Resources Where You Can Learn More

I encourage you to visit the website of the non-profit charity, the National Vaccine Information Center (NVIC), at www.NVIC.org:

  • NVIC Memorial for Vaccine Victims: View descriptions and photos of children and adults, who have suffered vaccine reactions, injuries and deaths. If you or your child experiences an adverse vaccine event, please consider posting and sharing your story here.
  • If You Vaccinate, Ask 8 Questions: Learn how to recognize vaccine reaction symptoms and prevent vaccine injuries.
  • Vaccine Freedom Wall: View or post descriptions of harassment and sanctions by doctors, employers, school and health officials for making independent vaccine choices.

Connect with Your Doctor or Find a New One That Will Listen and Care

If your pediatrician or doctor refuses to provide medical care to you or your child unless you agree to get vaccines you don’t want, I strongly encourage you to have the courage to find another doctor. Harassment, intimidation, and refusal of medical care is becoming the modus operandi of the medical establishment in an effort to stop the change in attitude of many parents about vaccinations after they become truly educated about health and vaccination.
However, there is hope.

At least 15 percent of young doctors recently polled admit that they’re starting to adopt a more individualized approach to vaccinations in direct response to the vaccine safety concerns of parents. It is good news that there is a growing number of smart young doctors, who prefer to work as partners with parents in making personalized vaccine decisions for children, including delaying vaccinations or giving children fewer vaccines on the same day or continuing to provide medical care for those families, who decline use of one or more vaccines.

So take the time to locate a doctor, who treats you with compassion and respect and is willing to work with you to do what is right for your child.

[-] Sources and References

Nancy Mullan MD
Author, Lecturer, clinician,
Dr. Nancy Mullan is best known for her natural treatment of chronic illness,
including Psychiatric Disorders, Autism Spectrum Disorders, Lyme and MTHFR+.

2829 Burbank Blvd., Suite 202, Burbank, CA 91505
T: (818) 954-9267 – F: (818) 954-0620
NancyMullanMD@aol.com
www.NancyMullanMD.com

 

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